Medical Questions

Latest Questions


Cetirizine — cetirizine not working for hives. it occurs again and again?

Posted 24 minutes ago • 0 answers

Gabapentin use for 4 months Help!?

Posted 48 minutes ago • 0 answers

I have been taking gabapentin for about 4 months. I usually take one or 2 300 mlg tablets a day so at most 600 mlg a day for 4 months. Today I decided to stop so haven’t taken any in over 24 hrs. How long till I feel normal again?

Can I take Metamucil while taking apo-rosuvastatin?

Posted 1 hour 23 minutes ago • 0 answers

My cholesterol level is high.

Spot for a couple hours day before period is due( had taken plan b two weeks prior)?

Posted 3 hours 55 minutes ago • 0 answers

Has anyone experienced spotting a day before your period is due? Only lasting the first half the day? I took plan b two weeks ago, second day of my fertility window. Experienced side effects a week after taking up until Now. Breast fullness, cramps, nauseous on and off, and really moody.

Can it take 6-8 weeks for buspar to work for some people?

Posted 6 hours ago • 2 answers

I’m 6’2 and 250 lbs (I’m a big guy).. I had the initial effect kick in after 2 weeks, then later my blood pressure improved and my high pulse dropped, and finally my constipation finally got better a few weeks later at week 5. I KNOW that this is the drug that works for me. Is it.

Fluconazole — Im back again! I have a dr appointment on monday but I need a little peace of mind.?

Posted 7 hours ago • 0 answers

Does Ashwagandha interact with prescriptions for heart problems?

Posted 9 hours ago • 0 answers

Bupropion/Wellbutrin side effects started after 5 weeks??

Posted 9 hours ago • 0 answers

The first 5 weeks on Bupropion XL 150g taken in the morning were fabulous! No drowsiness, no brain fog, or low mood, just the best version of myself, focused and energized. I’m finishing week 6 now, but for the past 5 days I’ve been feeling very tired and sleepy, confused and unable to.

Can I take «Tagamet» with some food instead of a full glass of water?

Posted 10 hours ago • 0 answers

The instructions says: take Tagamet with a full glass of water before eating food. My problem is that when I drink a full glass of water on an empty stomach, I instantly get bloated. Is it possible to take Tagamet, and then eat just a bit of food to make it go down into the stomach? Or does it.

My doc prescribed Effexor XR 37.5mg and I am concerned about sexual side effects?

Posted 11 hours ago • 3 answers

I am on prednisone. Can I drink while on this?

Posted 13 hours ago • 0 answers

I’m on 10mg tablets 3 times a day. Today is the 2nd day I have been on it.

What dosage of Apidra insulin needed with a reading of 155 before eating?

Posted 13 hours ago • 1 answer

Sliding scale dosage his range is 90 to 180

What pharmacy has light green xanax bar 4 sections with 2090 on it?

Posted 13 hours ago • 1 answer

How long does it take to get one 1mg of clonazepam out of your system?

Posted 14 hours ago • 1 answer

Clonazepam — Did anyone experience weight gain or weight loss?

Posted 16 hours ago • 2 answers Mobile Apps

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CFR — Code of Federal Regulations Title 21

The information on this page is current as of April 1 2019.

For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR).



Subpart A—General Provisions
§ 312.1 — Scope.
§ 312.2 — Applicability.
§ 312.3 — Definitions and interpretations.
§ 312.6 — Labeling of an investigational new drug.
§ 312.7 — Promotion of investigational drugs.
§ 312.8 — Charging for investigational drugs under an IND.
§ 312.10 — Waivers.

Subpart B—Investigational New Drug Application (IND)
§ 312.20 — Requirement for an IND.
§ 312.21 — Phases of an investigation.
§ 312.22 — General principles of the IND submission.
§ 312.23 — IND content and format.
§ 312.30 — Protocol amendments.
§ 312.31 — Information amendments.
§ 312.32 — IND safety reporting.
§ 312.33 — Annual reports.
§ 312.38 — Withdrawal of an IND.

Subpart C—Administrative Actions
§ 312.40 — General requirements for use of an investigational new drug in a clinical investigation.
§ 312.41 — Comment and advice on an IND.
§ 312.42 — Clinical holds and requests for modification.
§ 312.44 — Termination.
§ 312.45 — Inactive status.
§ 312.47 — Meetings.
§ 312.48 — Dispute resolution.

Subpart D—Responsibilities of Sponsors and Investigators
§ 312.50 — General responsibilities of sponsors.
§ 312.52 — Transfer of obligations to a contract research organization.
§ 312.53 — Selecting investigators and monitors.
§ 312.54 — Emergency research under 50.24 of this chapter.
§ 312.55 — Informing investigators.
§ 312.56 — Review of ongoing investigations.
§ 312.57 — Recordkeeping and record retention.
§ 312.58 — Inspection of sponsor’s records and reports.
§ 312.59 — Disposition of unused supply of investigational drug.
§ 312.60 — General responsibilities of investigators.
§ 312.61 — Control of the investigational drug.
§ 312.62 — Investigator recordkeeping and record retention.
§ 312.64 — Investigator reports.
§ 312.66 — Assurance of IRB review.
§ 312.68 — Inspection of investigator’s records and reports.
§ 312.69 — Handling of controlled substances.
§ 312.70 — Disqualification of a clinical investigator.

Subpart E—Drugs Intended to Treat Life-threatening and Severely-debilitating Illnesses
§ 312.80 — Purpose.
§ 312.81 — Scope.
§ 312.82 — Early consultation.
§ 312.83 — Treatment protocols.
§ 312.84 — Risk-benefit analysis in review of marketing applications for drugs to treat life-threatening and severely-debilitating illnesses.
§ 312.85 — Phase 4 studies.
§ 312.86 — Focused FDA regulatory research.
§ 312.87 — Active monitoring of conduct and evaluation of clinical trials.
§ 312.88 — Safeguards for patient safety.

Subpart F—Miscellaneous
§ 312.110 — Import and export requirements.
§ 312.120 — Foreign clinical studies not conducted under an IND.
§ 312.130 — Availability for public disclosure of data and information in an IND.
§ 312.140 — Address for correspondence.
§ 312.145 — Guidance documents.

Subpart G—Drugs for Investigational Use in Laboratory Research Animals or In Vitro Tests
§ 312.160 — Drugs for investigational use in laboratory research animals or in vitro tests.


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Frontline Reviews

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Applicator difficult. I currently have 4 cats, and have had cats for about 40 years. I have always used Frontline. However, I will no longer use it, due to the package being so difficult to open. When they began using the new packaging, I was not satisfied and continue to not be! It is too difficult to open. I will no longer use it!!

Sunday March 8th 2020 I administered Feline Frontline to my Cat who was 15 pounds and 10 years old. Monday March 9th 2020 I came home from work and found him lying in my bedroom floor having seizures. My husband and I wrapped him in a towel and started our way to the emergency vet. Before we made it to the end of our road we live on my beloved passed away. We adopted him when he was two years old. He was only an indoor cat and had just had a healthy checkup at the vet. I cannot honestly say that Front-Line caused his death but it is ironic. Kitty Heaven is he.

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Carey — 8 years old — mixed breed — 35 lbs. We applied Frontline Gold for the first time ever to our dog on 01/16/20. Within 5 hours she would randomly scream out in pain/because she was scared and jump into our arms. At the time we thought maybe she hurt her leg or back and would touch her spine, rotate her legs, etc. without finding any indication of soreness anywhere on her body. This would happen sporadically on Friday and Saturday. By Saturday evening, it was happening more frequently. And at this point we realized that our dog was having mild seizures. She was not losing consciousness, but she would cry out/get this look about her and then burrow into us and her whole little body would tense up, she would lick her lips (salivating), and stretch out her neck and put her head high into the air.

We took her to the emergency vet and they have since started her on seizure medication and a sedative for now because she is absolutely terrified when one starts to come on. Secondly, she is spending the day at her primary vet receiving fluids and staying under observation — and we will do this again tomorrow. Her behavior is different — she is very clingy — and she has tremors constantly. We feel completely helpless.

Carey was in perfect health prior to application of the Frontline Gold and nothing else has changed in her routine other than that. Frontline refuses to accept ANY responsibility. In fact, when we asked how to get their medication out of her, their only response was to bathe her — which we did 3 times. This medication is so poorly researched that they do not even have a way to reverse it if a dog has a reaction — and that is because according to them, «it is impossible for their product to cause these symptoms.»

We are really hoping to wean her off of the seizure meds by the end of the month once the Frontline should be worn off. I really hope she will be able to go back to normal once the poison is out of her body. Frontline should be ashamed of both the fact that they poorly researched this medication/did not provide accurate side effects to the customer, and the fact that they so easily just say it is impossible for their product to cause any of this. DO NOT USE THEIR PRODUCTS. It simply isn’t worth it.

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The most effective way to prevent infection from ­­­West Nile virus is to prevent mosquito bites. Mosquitoes bite during the day and night. Use insect repellent, wear long-sleeved shirts and pants, treat clothing and gear, and take steps to control mosquitoes indoors and outdoors.

Protect yourself and your family from mosquito bites

Use Insect Repellent

Use Environmental Protection Agency (EPA)-registered insect repellents external icon with one of the active ingredients below. When used as directed, EPA-registered insect repellents are proven safe and effective, even for pregnant and breastfeeding women.

  • DEET
  • Picaridin (known as KBR 3023 and icaridin outside the US)
  • IR3535
  • Oil of lemon eucalyptus (OLE)
  • Para-menthane-diol (PMD)
  • 2-undecanone

Find the right insect repellent for you by using EPA’s search tool external icon .

Tips for babies and children

  • Dress your child in clothing that covers arms and legs.
  • Cover strollers and baby carriers with mosquito netting.
  • When using insect repellent on your child:
    • Always follow label instructions.
    • Do not use products containing oil of lemon eucalyptus (OLE) or para-menthane-diol (PMD) on children under 3 years old.
    • Do not apply insect repellent to a child’s hands, eyes, mouth, cuts, or irritated skin.
      • Adults: Spray insect repellent onto your hands and then apply to a child’s face.

Tips for Everyone

  • Always follow the product label instructions.
  • Reapply insect repellent as directed.
    • Do not spray repellent on the skin under clothing.
    • If you are also using sunscreen, apply sunscreen first and insect repellent second.

Natural insect repellents (repellents not registered with EPA)

  • We do not know the effectiveness of non-EPA registered insect repellents, including some natural repellents.
  • To protect yourself against diseases spread by mosquitoes, CDC and EPA recommend using an EPA-registered insect repellent.
  • Choosing an EPA-registered repellent ensures the EPA has evaluated the product for effectiveness.
  • Visit the EPA website to learn more. external icon

Wear long-sleeved shirts and long pants

Treat clothing and gear

  • Use permethrin to treat clothing and gear (such as boots, pants, socks, and tents) or buy permethrin-treated clothing and gear.
    • Permethrin is an insecticide that kills or repels mosquitoes.
    • Permethrin-treated clothing provides protection after multiple washings.
    • Read product information to find out how long the protection will last.

    If treating items yourself, follow the product instructions.

  • Do not use permethrin products directly on skin.

Take steps to control mosquitoes indoors and outdoors

  • Use screens on windows and doors. Repair holes in screens to keep mosquitoes outdoors.
  • Use air conditioning, if available.
  • Stop mosquitoes from laying eggs in or near water.
    • Once a week, empty and scrub, turn over, cover, or throw out items that hold water, such as tires, buckets, planters, toys, pools, birdbaths, flowerpots, or trash containers.
    • Check indoors and outdoors.

Prevent mosquito bites when traveling overseas

  • Choose a hotel or lodging with air conditioning or screens on windows and doors.
  • Sleep under a mosquito bed net if you are outside or in a room that does not have screens.
    • Buy a bed net at your local outdoor store or online before traveling overseas.
    • Choose a WHOPES-approved bed net: compact, white, rectangular, with 156 holes per square inch, and long enough to tuck under the mattress.
    • Permethrin-treated bed nets provide more protection than untreated nets.
      • Do not wash bed nets or expose them to sunlight. This will break down the insecticide more quickly.
    • For more information on bed nets, visit CDC’s page on insecticide-treated bed nets.
    • For more information on traveling overseas, visit Travelers’ Health.

Mosquito Bite Prevention for the United States

How to Protect Against Mosquito Bites for Travelers

Mosquito Bites Can Make You Sick

Simple Random Sampling

Simple random sampling (also referred to as random sampling) is the purest and the most straightforward probability sampling strategy. It is also the most popular method for choosing a sample among population for a wide range of purposes. In simple random sampling each member of population is equally likely to be chosen as part of the sample. It has been stated that “the logic behind simple random sampling is that it removes bias from the selection procedure and should result in representative samples”[1].

Ideally, the sample size of more than a few hundred is required in order to be able to apply simple random sampling in an appropriate manner.[2] It can be argued that simple random sampling is easy to understand in theory, but difficult to perform in practice. This is because working with a large sample size is not easy and it can be a challenge to get a realistic sampling frame.

Simple random sampling

Many dissertation supervisors advice the choice of random sampling methods due to the representativeness of sample group and less room for researcher bias compared to non-random sampling techniques. However, application of random sampling methods in practice can be quite difficult due to the need for the complete list of relevant population members and a large sample size.

Other variations of random sampling include the following:

Application of Simple Random Sampling: an Example

Application of simple random sampling method involves the following stages:

  1. A list of all members of population is prepared. Each element is marked with a specific number (suppose from 1 to N).
  2. N items are chosen among a population size of This can be done either with the use of random number tables or random number generator software. The latter option is more preferable as the selection of random samples can be aided by software such as Research Randomizer and Stat Trek. In this way researcher bias can be minimized.

There are two popular approaches that are aimed to minimize the relevance of bias in the process of random sampling selection: method of lottery and the use of random numbers.

The method of lottery is the most primitive and mechanical example of random sampling. In this method you will have to number each member of population in a consequent manner, writing numbers in separate pieces of paper. These pieces of papers are to be folded and mixed into a box. Lastly, samples are to be taken randomly from the box by choosing folded pieces of papers in a random manner.

The use of random numbers, an alternative method also involves numbering of population members from 1 to N. Then, the sample size of N has to be determined by selecting numbers randomly. The use of random number table similar to one below can help greatly with the application of this sampling technique.

Random number table

Advantages of Simple Random Sampling

  1. If applied appropriately, simple random sampling is associated with the minimum amount of sampling bias compared to other sampling methods.
  2. Given the large sample frame is available, the ease of forming the sample group i.e. selecting samples is one of the main advantages of simple random sampling.
  3. Research findings resulting from the application of simple random sampling can be generalized due to representativeness of this sampling technique and a little relevance of bias.

Disadvantages of Simple Random Sampling

  1. It is important to note that application of random sampling method requires a list of all potential respondents (sampling frame) to be available beforehand and this can be costly and time-consuming for large studies.
  2. The necessity to have a large sample size can be a major disadvantage in practical levels
  3. This sampling method is not suitable for studies that involve face-to-face interviews covering a large geographical area due to cost and time considerations

My e-book, The Ultimate Guide to Writing a Dissertation in Business Studies: a step by step approach contains a detailed, yet simple explanation of sampling methods. The e-book explains all stages of the research process starting from the selection of the research area to writing personal reflection. Important elements of dissertations such as research philosophy, research approach, research design, methods of data collection and data analysis are explained in this e-book in simple words. John Dudovskiy

[1] Gravetter, F.J & Forzano, L.B. (2011) “Research Methods for the Behavioural Sciences” Cengage Learning p.146

[2] Saunders, M., Lewis, P. & Thornhill, A. (2012) “Research Methods for Business Students” 6 th edition, Pearson Education Limited

See also:  All About Mosquitoes, Waynes
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