Practitioner from ticks for dogs — effectiveness, indications for use, contraindications

Practitioner from ticks for dogs — effectiveness, indications for use, contraindications

What is Advocate ® ?
Advocate ® is a topical spot on for use on dogs and cats. Advocate ® is effective against fleas, flea larvae, ear mites, sarcoptic mange mites, demodectic mange mites, lice, immature and mature stages of roundworms, hookworms and adult whipworms and lungworms. It prevents heartworms, lungworms and skinworms and also treats circulating microfilaria.

At what age can Advocate ® be used on dogs and cats?
Advocate ® can be used on dogs from 7 weeks of age and over 1kg in weight. Advocate ® can be used on cats from 9 weeks of age and over 1kg in weight.

What are the active ingredients in Advocate ® for dogs and Advocate ® for cats?
Advocate ® for dogs: 10% imidacloprid & 2.5% moxidectin. Advocate ® for cats: 10% imidacloprid & 1% moxidectin.

Is the efficacy of Advocate ® affected by water?
Brief contact of the animal with water on one or two occasions between monthly treatments will notsignificantly reduce the efficacy of the product. However, immersion in water directly after treatment may reduce the efficacy of the product.

Is Advocate ® safe for use on pregnant and lactating dogs and cats?
Both active ingredients have individually shown no problems with use during pregnancy. Reproductive safety studies with Advocate ® have not been completed to date and thus the safety of Advocate ® has not been established during pregnancy and lactation.

Can I use Advocate ® for dogs on cats or Advocate ® for cats on dogs?
NO, as Advocate ® for dogs contains a different level of the active ingredient moxidectin than the level contained in the product for cats. The concentration of moxidectin for both is based on efficacy and drug behavior in each respective species. It is important to use the specific cat or dog product to ensure the product’s effectiveness in the target species.

What size of Advocate ® do I use on a cat over 8kg of body weight?
Cats over 8kg should be treated with the appropriate combination of tubes.

What size of Advocate ® do I use on a dog over 40kg?
Dogs weighing over 40kg should be treated with the appropriate combination of tubes.

Can I shampoo my dog after application?
Brief contact of the animal with water on one or two occasions between monthly treatments will not significantly reduce the efficacy of the product. However, frequent shampooing or immersion in water after treatment may reduce the efficacy of the product. Sebolytic shampoos strip the lipid layer completely. The lipid layer takes 1-4 days to regenerate. Advocate ® can be applied to animals treated with a sebolytic shampoo after this time period.

Is it important to test dogs for heartworm before applying Advocate ® ?
In endemic areas, Advocate ® may be safely administered to heartworm infected dogs. However, it is recommended that all dogs 6 months of age or over should be tested for patent heartworm infections before beginning prophylactic medication for the first time. Dogs that are heartworm positive should be treated appropriately.

Heartworm and travelling
Heartworm prevention is a must for pets travelling to or living in endemic areas. Heartworm status checks are recommended for pets who live in or have travelled to endemic areas.

Can you use advantix ® and Advocate ® concurrently in dogs?
Yes, to control fleas, as well as ticks, flies and mosquitoes the use of advantix ® and Advocate ® is necessary. Our suggestion is to first treat with Advocate® and then treat with advantix ® a week later or alternate on a 2-weekly basis.

Can Advocate ® be used concurrently with a Seresto ® collar?
Advocate ® can safely be used concurrently with Seresto ® also protect your pet against ticks.

NexGard chewables for Dogs

With the flea and tick infestation in dogs dramatically increasing, the number of flea and tick control medicines has also increased. However, there are only a few flea treatments that are not only effective but are easy to administer too. One such highly effective medicine is NexGard for dogs.

What is NexGard Chewables for dogs?

NexGard is an oral formulation that comes from the same company that manufactured the effective Frontline Plus; Merial. Since NexGard flea and tick preventative offers a number of benefits, it has become the top choice for many veterinarians. NexGard for dogs is a delicious chewable tablet that can kill the adult fleas even before they have a chance to lay eggs. Similarly, it can also kill ticks too. Considering the necessity of dosing your dog easily, NexGard for dogs is beef-flavored so that he or she considers it a treat!

Effectiveness of NexGard flea and tick preventative

Merial has come up with a new molecule called afoxolaner that is particularly designed to kill both ticks and fleas in dogs. NexGard Chewables for dogs should be given orally to the dog, and they provide protection for the entire month. NexGard Chewables for dogs can only be purchased with a prescription.

According to the company, when either the tick or the flea comes in contact with afoxolaner present in the dog, the chemical disturbs its central nervous system, leading to hyperexcitation, and eventually death. Afoxolaner not only prevents flea infestation by killing the fleas before they get to lay the eggs, but it also continues to kill the parasite for the whole month.

Advantages of NexGard chewable

There are multiple advantages of NexGard for dogs. Some of them are:

  • It is a fast acting formula which is more powerful as compared to other oral flea control medicines. Only one chew has the ability to kill both ticks and fleas. In fact, the medicine starts working only a few hours after initial administration, and in just 24 hours, 100% fleas can be killed.
  • Since it prevents a flea infestation by killing the adult fleas before they lay eggs, the medicine is effective and safe for the entire month.
  • It is a beef-flavored soft chew which is why dogs consume it readily. Moreover, dosing your dog is also easy since NexGard can be given both without food and with food and comes in a bite-sized chew.
  • It can help get rid of a variety of ticks such as brown dog tick, lone star tick, and black-legged tick.
  • There have been no adverse interactions with the use of NexGard up till now.
  • The medicine is suitable for puppies that are more than 8 weeks old. It is also safe to give NexGard for flea and tick to dogs weighing 4 pounds or more.
  • The medicine for flea control can also be used with other treatments such as anthelmintics, antibiotics, and vaccines.
  • Since NexGard Chewables for dogs is an oral treatment, you don’t have to worry about your dog when you take it for a swim or a bath
  • The medicine can also prevent subsequent flea infestations once the treatment for existing flea infestations has started.
  • The medicine also has a long shelf life since the expiration date is two years after the date of manufacture.

NexGard side effects

While NexGard side effects are quite rare, there are cases where they do occur. NexGard side effects your dog may experience include lack of appetite, vomiting, drowsiness, irritation, and diarrhea. If you notice any side effects or allergic reactions in your dog on the administration of the medicine, then your dog might be allergic to the chemical in the medicine; afoxolaner. While the chemical is considered safe, it might not be suitable for your dog.

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NexGard drug interactions

There haven’t been any known contraindications with the use of NexGard for flea and tick. However, just like with any medicine, make sure to inform your vet of other medications your pet is taking along with NexGard chewables including supplements and vitamin tablets.

Effectiveness of NexGard

In terms of the time it takes for the treatment to work, NexGard is quite fast; it can kill 100% fleas in just 24 hours. The medicine works, as mentioned earlier, by over-stimulating the nervous system of the fleas and ticks. Of course, you might see your beloved pet scratching and itching even after 24 hours, but that’s only a habitual reaction and will stop after two or three days.

Remember, for NexGard to be effective for your dog, different strengths are needed according to the size of your dog, just like other flea treatment options. If you find it difficult to determine the right dosage for you, you can ask your vet to do so. Your vet can ensure that only the right dosage is administered to your dog. With the correct application, you can provide a whole month of effective protection against ticks and fleas both!

Precautions to take when administering NexGard

While NexGard is considered safe for dogs, it is still better to take precautions.

  • There has been no evaluation done yet for the use of NexGard in breeding males and females both.
  • Do not use in those dogs that have a history of seizures. For the safety of your dog, it is crucial first to consult your dog before you use any medicine on it.
  • Make sure to keep NexGard away from children since the product is not suitable for human consumption.
  • Just like handling other medications, make sure to wash your hands thoroughly after you give NexGard to your dog.


Treating your dog with NexGard will ensure that fleas and ticks are killed. At the same time, the medicine also protects your dog against harmful parasite-infested diseases apart from flea infestation. When it comes to pet care, it is best to choose only the best which is why NexGard is a smart choice. With no known NexGard side effects and numerous benefits, the medicine is ideal for your furry friend. Get yours today here!

All information provided is without warranty or guarantee. This website can never displace a veterinarian. If you have any questions about your pet please make sure to contact a veterinarian to get medical advice.

Who should not take Gabapentin?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • suicidal thoughts
  • depression
  • myasthenia gravis
  • a skeletal muscle disorder
  • decreased lung function
  • pregnancy
  • chronic obstructive pulmonary disease
  • chronic kidney disease stage 3A (moderate)
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function


Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Drontal Plus

Generic Name: praziquantel/pyrantel pamoate/febantel chewable tablets

On This Page

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.


Drontal® Plus Taste Tabs® (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Chewable Anthelmintic Tablets for Dogs are available in three tablet sizes. Each size is scored for convenient oral administration.

Each Drontal Plus Taste Tabs Tablet for Puppies and Small Dogs contains 22.7 mg praziquantel, 22.7 mg pyrantel base as pyrantel pamoate and 113.4 mg febantel.

Each Drontal Plus Taste Tabs Tablet for Medium Sized Dogs contains 68.0 mg praziquantel, 68.0 mg pyrantel base as pyrantel pamoate and 340.2 mg febantel.

Each Drontal Plus Taste Tabs Tablet for Large Dogs contains 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate, and 680.4 mg febantel.


Drontal® Plus Taste Tabs® Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited.1 Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces.

Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite.2

Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal. Available information suggests that the parasite’s energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.

Laboratory efficacy and clinical studies conducted with Drontal Plus Anthelmintic Tablets demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths.


Drontal® Plus (praziquantel/pyrantel pamoate/febantel) Taste Tabs® Broad Spectrum Chewable Anthelmintic Tablets are indicated for removal of Tapeworms ( Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus,and removal and control of Echinococcus multilocularis) and for removal of Hookworms ( Ancylostoma caninum, Uncinaria stenocephala), Ascarids ( Toxocara canis, Toxascaris leonina), and Whipworms ( Trichuris vulpis) in dogs.


DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.8 The effects of Drontal® Plus Anthelmintic Tablets on pregnant animals have not been determined.

There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.




Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with Drontal® Plus Taste Tabs® Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater.7 All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.


DOSAGE: The presence of parasites should be confirmed by laboratory fecal examination. Weigh the animal before treatment. Administer the proper dosage as specified in the following table as a single oral treatment.

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for Puppies and Small Dogs*

for Medium Sized Dogs

(45 lbs. and greater)


Most dogs find Drontal® Plus Taste Tabs® Tablets palatable. The tablets may be offered to the dog by hand. Alternatively tablets may be given directly by mouth or offered in a small amount of food. Fasting is neither necessary nor recommended prior to or after treatment.

For those animals living where reinfections are likely to occur, clients should be instructed in the steps to optimize prevention; otherwise, retreatment may be necessary. This is true in cases of Dipylidium caninum where reinfection is almost certain to occur if fleas are not removed from the animal and its environment. In addition, for control of Echinococcus multilocularis, a program of regular treatment every 21 to 26 days may be indicated (see E. multilocularis section below).

Echinococcus multilocularisis a tapeworm species usually found in wild canids, including foxes, coyotes and wolves. The parasite has also been identified in domestic dogs and cats and is potentially a serious public health concern because it may infect humans.

The life cycle of the parasite is based on a predator-prey relationship as depicted.

The adult tapeworm is small (1-4mm) and resides in the intestinal tract of the definitive host (wild or domestic canids). Eggs from the adult tapeworm are shed in the feces. Rodents such as mice and voles serve as the intermediate host. Eggs ingested by rodents develop in the liver, lungs and other organs to form multilocular cysts. The life cycle is completed after a canid consumes a rodent infected with cysts. Larvae within the cyst develop into adult tapeworms in the intestinal tract of the canid. Eggs may be passed in the feces of the canid approximately 28 days later.

This parasite poses a serious public health problem because of the possibility for human involvement in the life cycle. If eggs shed by an infected canid are accidentally ingested, a highly pathogenic condition (Alveolar Hydatid Disease) results from development of the cyst stage in humans.

The original geographic distribution of E. multiloculariswas primarily confined to northern areas of North America. Current evidence indicates migration of the parasite well into the continental United States. 3 , 4

Domestic dogs living in E. multilocularisendemic areas that roam freely with the opportunity to catch wild rodents are at risk of infection. Pet owners should be advised on how to minimize this risk. Proper restraint of dogs should be encouraged, along with regular treatment with Drontal® Plus Taste Tabs® Tablets, following the dosing schedule aforementioned and precautions indicated below.

Additional information on the life cycle and epidemiology of this parasite is available in veterinary parasitology texts. 5 , 6


Diagnosis of E. multilocularis in canids is difficult. The adult tapeworm produces no clinical signs of infection. Tapeworm segments (proglottids) are usually not observed in the feces. E. multilocularis eggs, observed using microscopic fecal examination procedures, are similar in appearance to those of common species such as Taenia pisiformis. Assistance in the diagnosis of E. multilocularismay be available from a state veterinary diagnostic laboratory. Additional information regarding areas where E. multilocularisis suspected or has been confirmed may be obtained from area veterinary schools or the Centers for Disease Control in Atlanta, GA.


Dogs infected with E. multilocularis should be treated to prevent exposure of humans to infective eggs and to break the parasite’s life cycle.

The dosage of Drontal® Plus Taste Tabs® Tablets for removal of E. multilocularis is the same as that indicated for the removal of the other tapeworm species listed on the label. Laboratory efficacy studies conducted with Drontal Plus tablets have demonstrated the recommended dosage is 100% effective.

Under condition of continual exposure to wild rodents, retreatment of the dog at 21-26 day intervals is recommended to prevent the shedding of infectious eggs.


A total of 176 dogs and puppies with naturally acquired or experimental parasite infections were included in 4 well-controlled laboratory studies to establish the efficacy of Drontal® Plus Anthelmintic Tablets. In addition, 103 dogs and puppies were included in clinical field studies conducted in 5 veterinary clinics at different geographic locations throughout the United States to further evaluate safety and efficacy. These studies included dogs of various sizes, ages and breeds. Data from these studies demonstrated Drontal Plus Anthelmintic Tablets are safe and efficacious for the removal of the parasite species indicated on the label when used as directed. Results obtained in the laboratory and clinical studies indicate small numbers of hookworm or roundworm eggs may be passed in the feces for up to 7 days after treatment although the worms themselves were eliminated. A follow-up fecal examination should be conducted 2 to 4 weeks after treatment to determine the need for retreatment.

Palatability studies with Drontal® Plus Taste Tabs® Tablets were conducted at 3 different veterinary clinics in the United States. These studies included a total of 151 dogs (65 males / 86 females) representing 34 different breeds with body weights ranging from 3.8 – 190 lbs. The tablets were offered free-choice to the dogs by their owners and over 89% of the dogs willingly consumed the tablets.


None of the 103 dogs treated with Drontal® Plus Anthelmintic Tablets in the clinical field studies exhibited drug-related side effects. Of the 40 dogs treated with Drontal Plus Taste Tabs® Tablets in laboratory studies, two dogs exhibited vomiting, one puppy exhibited bloody/mucoid stool and one puppy exhibited watery/profuse stool.

For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-633-3796. For medical emergencies or to report adverse reactions, call 1-800-422-9874.


Controlled safety evaluations have been conducted in dogs with Drontal® Plus (praziquantel/pyrantel pamoate/febantel) Anthelmintic Tablets. Dogs receiving up to 5 times the label dosage (35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight) for 3 consecutive days (3 times the label duration) showed clinical signs of vomition and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings (outside of normal range) at 6 days post-treatment. No additional findings were noted in hematology/clinical chemistry parameters nor were there any treatment-related histological lesions. Vomition was the only side effect observed when dogs received a single treatment of 61 mg praziquantel, 61 mg pyrantel pamoate and 305 mg febantel/kg with one dog having an elevated SGPT reading (outside of normal range) at 24 hours post-treatment which had returned to normal by 7 days.


Drontal® Plus Taste Tabs® Tablets should be stored at or below 77 °F (25 °C).

Un-blistered whole or partial tablets should be stored in a tightly sealed container.

How is Drontal Plus Supplied

Drontal® Plus Taste Tabs® Tablets are available in three tablet sizes:

Code 08758428: 40 tabs/box for Puppies and Small Dogs

Code 08892051: 40 tabs/box for Medium Sized Dogs

Code 08892078: 30 tabs /box for Large Dogs


1 Andrews P. 1976. Pharmacokinetic Studies with DRONCIT® in Animals Using a Biological Assay. Veterinary Medical Review. 2:154-165.

2 Campbell WC. 1986. The Chemotherapy of Parasitic Infections. J. Parasit. 72(1):45-61.

3 Hildreth MB Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 13(5): 727-740.

4 PD Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, Ill. Host Occurrence and Geographic Distribution of Echinococcus multilocularisin the North Central United States. J. Parasit. 56(6): 1141-1150.

5 Georgi JR and Georgi ME. 1990. Parasitology for Veterinarians. W.B. Saunders Co. 118-138.

6 Soulsby EJL. 1982. Helminths, Arthropods and Protozoa of Domesticated Animals. 7th Edition. Lea & Febiger. 118-138.

7 Craig PS and McPharson CNL. 1988. Sodium Hypochlorite as an Ovicide for Echinococcus. Ann Trop Med. and Parasit. 82(2): 211-213.

8 Freedom of Information Summary (FOI) NADA 133-953 Vercom Paste (febantel and praziquantel).

Bayer HealthCare LLC

Animal Health Division

Shawnee Mission, Kansas 66201 USA

NADA 141-007, Approved by FDA

January, 2006 ©2006 Bayer HealthCare LLC

R.0 Bayer, the Bayer Cross, Drontal, and Taste

12894 Tabs are registered trademarks of Bayer

Bravecto For Dogs

Bravecto is a relatively new product released in 2014 which can provide long-lasting protection from fleas and ticks (black-legged tick, American dog tick, brown dog tick and lone star tick), or treat existing infestations. It contains the active ingredient fluralaner, a type of isoxazoline which maintains protection for 12 weeks, meaning you only have to use the medicine as a preventative roughly once every 3 months. There is some discussion about its safety which we will explore from an unbiased perspective later in the article.

How does it compare to Comfortis and Capstar?

Comfortis and Capstar are two other popular flea treatments. Unlike Bravecto, Comfortis does not kill ticks and needs to be given every month, and Capstar is not effective as a flea preventative. Which medicine you choose will come down to personal preference and how well your dog tolerates each of them.

Safer Treatment for Fleas & Ticks

As you may have read online, many owners believe Bravecto has severely harmed their dog. As a safe alternative, this shampoo kills fleas, ticks, and mange mites on contact.

What’s The Correct Dosage?

Note: Bravecto is a prescription-only medicine, speak to your vet before use. It should not be purchased or used unless a licensed vet has given you permission to do so.

Because fluralaner remains active against fleas and ticks for 12 weeks, you will only need to administer Bravecto once every 12 weeks (or once every 8 weeks if you require protection from lone star ticks). The minimum target dose of fluralaner is around 11.4 mg/lb, but different boxes are made for different sizes of dog to make dosing easier. See the table below for the amount of tablets you should give to your dog per dose.

Weight of dog (lbs)

4.4 – 9.9 One yellow box tablet (112.5 mg)
10 – 22 One orange box tablet (250 mg)
22.1 – 44 One green box tablet (500 mg)
44.1 – 88 One blue box tablet (1000 mg)
88.1 – 123 One pink box tablet (1400 mg)
Over 123 Use an appropriate combination.

If your dog weighs more than 123 lbs you will need to give him an appropriate combination of chews to reach the desired dose. Which tablets you use will depend on the size of the dog being treated. For example, if your dog is 150 lbs, you could give him two blue box chews per dose, which would cover dogs weighing anywhere from 88.2 to 176 lbs.

Because the chews are palatable, most dogs will take them immediately, but if not, offering them with food will often help. Giving the chews with food is recommended in any case to reduce the risk of vomiting. If you still have difficulties getting your dog to take the medicine you can try using GREENIES pill pockets.

How quickly does it work?

Fluralaner takes effect quickly and begins killing fleas (adult and juvenile) within 2 hours, and ticks within 12 hours.

Is It Safe?

Fluralaner (the product’s active ingredient) is approved by the FDA for use in dogs. It should only be given to dogs who are both 6 months of age or older and 4.4 lbs or heavier. In trials it has been given alongside anthelmintics (a group of antiparisitic drugs which includes Panacur), antibiotics, steroids and vaccines without causing any adverse reactions. It has also shown to be safe for pregnant and nursing animals.

Reports on the safety of fluralaner:

The following links contain important information about the safety of fluralaner, including investigations into popular social media rumors.

“Does Bravecto Kill Dogs?” Facebook Group – A group on Facebook where owners report possible side effects their dog has experienced as a result of Bravecto. This evidence is anecdotal, but should still be taken into consideration.

CVM ADE: Report of side effects – This document contains a list of reported side effects to help you make an informed decision about treatment.

Investigation into Bravecto by Snopes – Snopes is a website which investigates and puts facts to rumors. They have investigated reports circulating social media about the dangers of fluralaner and have deemed these reports to be unproven.

Considering the reports written by owners about bad reactions, it is wise to practice caution and speak about any concerns with your vet. If you notice your dog losing his appetite, throwing up food, becoming lethargic, or developing symptoms which mimic a urinary tract infection (e.g. urinary retention or incontinence and cloudy urine), we recommend speaking to your vet and possibly testing kidney and liver values just to be safe.

FDA Status: Fluralaner is FDA-approved for veterinary use under application number 141-426.

Safety Guidelines

To use Bravecto correctly please follow these guidelines:

    Seek advice from your vet before beginning treatment

Even though there are no listed contraindications and the product does not interact with the most frequently used veterinary medicines, be sure to tell the vet about any medical conditions your dog suffers from, as well as any other medicines and supplements you are treating him with.

  • Only give to dogs who weigh at least 4.4 lbs and who are at least 6 months old
  • Sign up for reminders so you don’t forget when the next dose is due
  • Give each dose of Bravecto with food to reduce the risk of vomiting
  • Watch your dog in case of a bad reaction and report any side effects to the vet
  • Consider monitoring kidney and liver function
  • The “reminders” service is free and highly recommended. When you only give the chews once every 12 weeks it can become difficult to remember when the next tablet is due, so these alerts can come in handy.

    What Is It Used For?

    This product has the following uses:

    It can provide protection from fleas for around 3 months at a time.

    Treat tick and flea infestations

    It works to kill adult fleas 2 hours after the tablet is given and remains effective for 12 weeks. It can also kill black-legged, brown dog and American dog ticks for 12 weeks, but loses its effectiveness against lone star ticks after 8 weeks (about 2 months).

    Fluralaner is not an effective treatment or preventative for worms. To prevent or treat cases of worms you should use a deworming medicine such as fenbendazole. Fenbendazole (the active ingredient of Panacur) is a type of broad-spectrum anthelmintic which should not cause any adverse reactions when given alongside fluralaner.

    Side Effects

    Bravecto may cause these adverse effects:

    Most Common

    • Vomiting (by far the most common)
    • Loss of appetite
    • Increased thirst
    • Weight loss
    • Lethargy
    • Diarrhea
    • Itching
    • Gas


    • Edema
    • Changes in behavior
    • Increased thirst
    • Blood in stools
    • Hyperemia
    • Seizures

    More side effects (some very serious) have been reported by owners on Facebook and on various forums.

    Contact the vet if you notice your dog becoming lethargic, losing appetite/throwing up food and developing symptoms similar to those seen with urinary tract infections, or if your dog experiences any serious reactions to the drug. You should also report these to Merck Animal Health on 1-800-224-5318. In cases of overdose always seek veterinary attention, as dogs who receive an overdose can experience blood in stools, seizures (particularly if they are predisposed to seizure activity) and an even higher chance of vomiting.

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