Benzyl benzoate Topical Advanced Patient Information

Benzyl benzoate (Topical)

Chemical Class: Benzoic Acid

Medically reviewed by Drugs.com. Last updated on Jul 10, 2019.

Uses for benzyl benzoate

Benzyl benzoate is used to treat lice and scabies infestations. Benzyl benzoate is believed to be absorbed by the lice and mites and to destroy them by acting on their nervous system.

Benzyl benzoate is available without a prescription.

Before using benzyl benzoate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For benzyl benzoate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to benzyl benzoate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of benzyl benzoate in children with use in other age groups, benzyl benzoate is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of benzyl benzoate in the elderly with use in other age groups. However, older people may have dry skin and the medicine may make the condition worse.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of benzyl benzoate. Make sure you tell your doctor if you have any other medical problems, especially:

  • Inflammation of the skin (severe)—Use of benzyl benzoate may make the condition worse

Proper use of benzyl benzoate

Benzyl benzoate usually comes with patient directions. Read them carefully before using benzyl benzoate.

Use benzyl benzoate only as directed. Do not use more of it and do not use it more often than recommended on the label. To do so may increase the chance of absorption through the skin and the chance of side effects.

Keep benzyl benzoate away from the eyes and other mucous membranes, such as the inside of the nose, because it may cause irritation . If you accidentally get some in your eyes, flush them thoroughly with water at once.

Do not use benzyl benzoate on open wounds, such as cuts or sores on the skin or scalp. To do so may increase the amount of absorption, which may increase the chance of side effects.

Your sexual partner or partners, especially, and all members of your household may need to be treated also, since the infestation may spread to persons in close contact. If these persons have not been examined for infestation or if you have any questions about this, check with your doctor.

To use benzyl benzoate for lice:

  • If your hair has any cream, lotion, ointment, or oil-based product on it, shampoo, rinse, and dry your hair and scalp well before applying benzyl benzoate.
  • Apply enough medicine to thoroughly wet the dry hair and scalp or skin.
  • Allow the medicine to remain on the affected areas for 24 hours.
  • Then, thoroughly wash the affected areas with warm water and soap or regular shampoo.
  • Rinse thoroughly and dry with a clean towel.
  • After rinsing and drying, use a fine-toothed comb (less than 0.3 mm between the teeth) to remove any remaining nits (eggs) or nit shells from your hair, or, if you have fine hair, you may use a tweezer or your fingernails to pick nits out.

To use benzyl benzoate for scabies:

  • If your skin has any cream, lotion, ointment, or oil on it, wash, rinse, and dry your skin well before applying benzyl benzoate.
  • If you take a bath or shower before using benzyl benzoate, dry the skin well before applying the medicine.
  • Apply enough medicine to cover the entire skin surface from the neck down, including the soles of your feet, and rub in well.
  • Allow the medicine to remain on the body for 24 hours.
  • Then, thoroughly wash the body with warm water and soap.
  • Rinse thoroughly and dry with a clean towel.

Immediately after using benzyl benzoate, wash your hands to remove any medicine that may be on them.

Treatment may need to be repeated for severe infestation.

Dosing

The dose of benzyl benzoate will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of benzyl benzoate. If your dose is different, do not change it unless your doctor tells you to do so.

See also:  Control of the strawberry mite, Phytonemus pallidus (Banks) in strawberry plantations by alternative acaricides

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (emulsion):
    • For lice infestation:
      • Adults—Use just one time. For severe cases, treatment may be repeated two or three times after twenty-four hours.
      • Children—
        • For infants: Use mixed with three parts of water, just one time.
        • For older children: Use mixed with an equal quantity of water, just one time.
    • For scabies infestation:
      • Adults—Use just one time. For severe cases, treatment may be repeated after twenty-four hours one time anytime within five days.
      • Children—
        • For infants: Use mixed with three parts of water, just one time.
        • For older children: Use mixed with an equal quantity of water, just one time.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions while using benzyl benzoate

To prevent reinfection or spreading of the infection to other people, good health habits are required. These include the following:

  • For lice infestation:
    • Disinfecting or washing combs, curlers, and brushes in very hot water (65 °C or 150 °F) for about 10 minutes immediately after using.
    • Washing in very hot water all recently worn clothing and used bed linens and towels, and drying them in a hot dryer for at least 20 minutes. Articles that cannot be washed may be dry-cleaned, pressed with a hot iron, or just placed in a hot dryer.
    • Sealing stuffed toys and other non-washable articles in a plastic bag for 2 weeks, or placing these items in the freezer (in sealed plastic bags) for 12 to 24 hours.
    • Vacuuming all rugs, mattresses, pillows, furniture, and car seats to get rid of fallen hairs with lice.
  • For scabies infestation: Washing all recently worn clothing such as underwear and pajamas, and used sheets, pillowcases, and towels in very hot water or dry-cleaning.

Benzyl benzoate side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Symptoms of overdose

  • Blister formation, crusting, itching, oozing, reddening, or scaling of skin
  • difficulty in urinating (dribbling)
  • jerking movements
  • sudden loss of consciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Burning or itching of skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.

www.drugs.com

Benzyl Benzoate (Topical)

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

* Not commercially available in the U.S.

† Not commercially available in Canada.

Note: Because benzyl benzoate is not commercially available in the U.S. or Canada, the bracketed information and the use of the superscript 1 in this monograph reflect the lack of labeled (approved) indications for this medication.

Accepted

[Pediculosis (treatment)] 1 —Benzyl benzoate is used in the topical treatment of pediculosis caused by Pediculus capitis (head louse) and Phthirus pubis (pubic or crab louse).

[Scabies (treatment)] 1 —Benzyl benzoate is used in the topical treatment of scabies caused by the Sarcoptes scabiei mite.

1 Not included in Canadian product labeling.

Physicochemical characteristics:
Source—
Prepared synthetically by the esterification of benzoic acid with benzyl alcohol.
Molecular weight—
212.2

Mechanism of action/Effect:

In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Absorption:

If topical benzyl benzoate is systemically absorbed, it is rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.

Elimination:
Excreted in the urine primarily as hippuric acid.

Precautions to Consider

Mutagenicity

Benzyl benzoate has not been shown to cause mutagenic effects.

Pregnancy/Reproduction

Appropriate studies on the relationship of age to the effects of benzyl benzoate have not been performed in the pediatric population. However, no pediatrics-specific problems have been documented to date.

Although appropriate studies on the relationship of age to the effects of benzyl benzoate have not been performed in the geriatric population, no geriatrics-specific problems have been documented to date. However, elderly patients are more likely to have age-related xerosis of the skin, which may make their skin more susceptible to the drying effects of benzyl benzoate, and irritation may be worse in this age group. An alternative medication may need to be considered.

Medical considerations/Contraindications
The medical considerations/contraindications included have been selected on the basis of their potential clinical significance (reasons given in parentheses where appropriate)— not necessarily inclusive (» = major clinical significance).

Note: Benzyl benzoate applied topically at recommended doses appears to have a low order of toxicity.

The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)—not necessarily inclusive:

Those indicating need for medical attention only if they continue or are bothersome
Incidence less frequent or rare

See also:  Be prepared for ambulance wait times

Irritation of skin, slight (burning sensation; itching)

Overdose
For more information on the management of overdose or unintentional ingestion, contact a Poison Control Center (See Poison Control Center Listing ).

To decrease absorption:
For accidental ingestion, emesis or gastric lavage should be induced.

Specific treatment:
The body should be washed with soap and warm water to remove excess benzyl benzoate.

Anticonvulsants may be given to control convulsions.

Supportive care:
Symptomatic treatment.

Patient Consultation
As an aid to patient consultation, refer to Advice for the Patient, Benzyl Benzoate (Topical).

In providing consultation, consider emphasizing the following selected information (» = major clinical significance):

Before using this medication
» Conditions affecting use, especially:
Sensitivity to benzyl benzoate

Pregnancy—Not recommended for use in pregnant women unless considered essential

Breast-feeding—Suspension of breast-feeding recommended during treatment

» Importance of using the medication only as directed

» Avoiding contact with the eyes and mucous membranes

» Not using on open wounds, such as cuts or sores on skin or scalp, to minimize systemic absorption

If necessary, treating other members of household and close contacts, especially sexual partner or partners, since infestation may spread to persons in close contact; checking with doctor if these persons have not been examined or if there are any questions

Applying enough benzyl benzoate to thoroughly wet the dry hair and scalp or skin

Leaving benzyl benzoate on affected areas for 24 hours

Removing benzyl benzoate by washing thoroughly with soap or with regular shampoo and warm water

Rinsing thoroughly; drying with clean towel

When hair is dry, combing with a fine-toothed comb (less than 0.3 mm between the teeth) to remove any remaining nits or nit shells, or using tweezers or fingernails to pick out nits for persons with fine hair

Drying skin well if bath or shower is taken before use of benzyl benzoate

Applying enough benzyl benzoate to dry skin to cover entire skin surface from neck down, including soles of feet; rubbing in well

Leaving benzyl benzoate on skin for 24 hours

Removing benzyl benzoate by washing thoroughly with soap and warm water

Rinsing thoroughly; drying with clean towel
Washing hands immediately after using to remove any benzyl benzoate that may be on them

Repeating treatment for severe infestation

» Proper storage

Precautions while using this medication

To help prevent reinfestation or spread of infestation to other persons

For lice
Disinfecting or washing combs, curlers, and brushes in very hot water for about 10 minutes immediately after using

Washing all recently worn clothing and used bed linens and towels in very hot water or dry-cleaning

Sealing stuffed toys and other non-washable articles in a plastic bag for 2 weeks, or placing these items in the freezer (in sealed plastic bags) for 12 to 24 hours

Vacuuming all rugs, mattresses, pillows, furniture, and car seats to remove fallen hairs with lice

For scabies
Washing all recently worn clothing such as underwear and pajamas, and used sheets, pillowcases, and towels in very hot water or dry-cleaning

General Dosing Information
To minimize systemic absorption, benzyl benzoate should not be used on open wounds, such as cuts or sores on skin or scalp.

Sexual partners and other persons in close contact or living in the same household should be checked for infestation and treated if necessary, since the infestation may spread to persons in close contact .

To help prevent reinfestation or spreading of the infestation, all recently worn clothing such as underwear and pajamas, and used sheets, pillowcases, and towels should be washed in very hot water or dry-cleaned .

Itching due to circulating antigens from scabies may persist for up to 2 weeks after successful treatment. Further treatment with benzyl benzoate is not advisable; use of a topical corticosteroid is recommended.

Treatment may be repeated for severe infestation .

A follow-up examination one week after the last treatment is recommended to confirm disinfestation of lice .

For treatment of adverse effects
Recommended treatment consists of the following

• For severe skin reaction, the medication should be washed off with soap and warm water.

Topical Dosage Form

Note: Because benzyl benzoate is not commercially available in the U.S. or Canada, the bracketed information and the use of superscript 1 in the Dosage Forms section reflect the lack of labeled (approved) indications for this product.

BENZYL BENZOATE EMULSION

Usual adult and adolescent dose
[Pediculosis] 1
Topical, one application to the affected areas as a 25% emulsion; emulsion should remain on the affected areas for twenty-four hours. Treatment may be repeated two or three times, if necessary, for severe infestation.

[Scabies] 1
Topical, one application to the entire body except the head and face as a 25% emulsion, which should remain for twenty-four hours. Treatment may be repeated anytime within five days if necessary. Alternatively, the emulsion may be applied three times at twelve-hour intervals.

Strength(s) usually available
U.S.—
Not commercially available.

Canada—
Not commercially available.

Other (United Kingdom)—

References

  1. Dollery C, editor. Therapeutic drugs. Edinburgh: Churchill Livingstone, 1991: 53-4.
  1. Ascabiol package insert (May and Baker, Rhone-Poulenc—UK), Rev 7/90, Rec 8/93.
  1. Robertson D, Maibach H. Dermatologic pharmacology. In Katzung BG, editor. Basic and clinical pharmacology. Norwalk: Appleton and Lange, 1992: 871-7.
  1. Ascabiol data sheet (Rhone-Poulenc Rorer—UK), Rec 8/93.
  1. Reynolds JEF, editor. Martindale, the extra pharmacopeia. 30th ed. London: The Pharmaceutical Press, 1993: 1124.
  1. Landegren J, Borglund E, Storgards K. Treatment of scabies with disulfiram and benzyl benzoate emulsion: a controlled study. Acta Derm Venereol (Stockh) 1979; 59(3): 274-6.
  1. Gray AMH. Treatment of scabies. BMJ 1942; 2: 170-3.
  1. McEvoy GK, editor. AHFS Drug information 93. Bethesda, MD: American Society of Hospital Pharmacists, 1993: 2199.
  1. Koren G, editor. Maternal-fetal toxicology. A clinicians’ guide. New York: Marcel Dekker, Inc., 1990: 59.
  1. Monthly Index of Medical Specialties. London: Haymarket Publishing Services Ltd., 1993 Feb: 239.
  1. VA Medication Classification System. USP DI 1993: 2862.
  1. Dewar J, editor. The practical touch. Can Pharm J 1993; 1(3): 1.
  1. Orkin M, Epstein E Sr, Maibach HI. Treatment of today’s scabies and pediculosis. JAMA 1986; 236: 1136-9.
  1. Burkhart CG. Scabies: an epidemiological reassessment. Ann Intern Med 1983; 98: 498-503.
  1. Panel comment, 11/93.
  1. Panel comment, 11/93.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

See also:  Gooseberry ognevka (photo): signs of infection and struggle

www.drugs.com

Benzyl benzoate

Medical expert of the article

Benzyl benzoate is an antiparasitic agent used externally.

[1], [2], [3], [4], [5]

ATC classification

Active ingredients

Indications Benzyl benzoate

Indications for the appointment of this drug are pediculosis and scabies.

[6], [7], [8]

Release form

Produced as a cream, in a tube of 40 or 80 g. One package contains 1 tube.

Other names — ointments Benzyl benzoate grindeks, as well as Benzyl benzoate-darnitsa.

[9], [10], [11], [12]

Pharmacodynamics

The active ingredient has a toxic effect on the scabies mite, and with it on all types of lice (they die after 2-5 hours, and the mites — after 7-32 minutes). The medicine penetrates through the chitinous membrane and begins to accumulate inside the tick’s body, acquiring a toxic concentration. Under its influence, adult mites die, as well as their larvae. But on the eggs of parasites the drug does not work.

[13], [14], [15], [16], [17]

Use Benzyl benzoate during pregnancy

The medicine can not be used by pregnant women. In the case of treatment during the lactation period, it is necessary to stop breastfeeding.

Contraindications

Among the contraindications of the medicine:

  • high sensitivity to benzyl benzoate, and in addition to other elements of drugs;
  • The presence of lesions on the skin (amongst these are also pustular lesions of the skin);
  • children’s age is less than 3 years.

[18], [19], [20]

Side effects Benzyl benzoate

After rubbing the cream into the skin surface, a burning sensation may appear, which disappears in the course of further use of the product. Occasionally, people with sensitive skin may experience local reactions — itching, burning, dryness or redness in the area that has been treated with the drug, and in addition, the development of allergies.

If the above described side effects do not go away on their own, you should cancel the use of the cream.

According to observations, the sensitivity of the epidermis is most intense in the genital area, as well as in places where the skin has been damaged.

Occasionally the contact form of dermatitis develops. Because the cream contains propylene glycol substance, irritation of the skin can develop.

[21], [22], [23], [24], [25]

Dosing and administration

Use 25% cream Benzyl benzoate is needed topically. In the process of one treatment it is required to apply 10-15 grams of medication. Children are allowed to apply the product to any areas of the skin, but adults can not handle the cream face and head under the hair.

In the process of removing scabies, before using the drug, take a shower (hot), using a soap that eliminates scales with scales. This soap needs to be completely rinsed off, then dry it dry, and then carry out the treatment procedure (it is recommended to perform it in the evening, before going to bed). During the treatment of scabies, the body should be treated in such a sequence: hands in turn, then the body (except the face, and also the skin under the hair), and then the legs and soles with the fingers. In areas with sensitive epidermis (areas of the genitals and groin, as well as mammary glands), and in addition with dermatitis, eczema or pyoderma, rub the drug is not recommended. After performing the procedure for 3 hours you can not wash your hands. Sometimes after the drug dries (as a rule, after 1 hour) another layer of drugs is applied. At the end of the procedure, the patient should wear clean clothes, as well as change clothes on the bed. After 24-48 hours, take a shower and again change the bed with clothes. The treatment should be performed for 2 weeks (4 times, 3-4 days apart). During the treatment course, about 60-90 g of medication is used.

To eliminate scabies, children under 5 years of age should be diluted the cream with boiled water of warm temperature (30-35 ° C) in proportions of 1k1 immediately before starting the treatment, and then stir until the emulsion has a uniform consistency. The procedure is usually performed without first taking a warm bath, twice a day with an interval of 12 hours.

To eliminate cortical scabies, it is required to remove the crusts from the skin beforehand by using keratolytic drugs. The duration of the treatment course is calculated in accordance with the dynamics of cleansing the skin surface, the disappearance of itching, as well as the completion of relief of the focus of inflammation.

To get rid of pediculosis, the medicine is gently rubbed into the skin under the hairline, after which the head is tied with a tissue. After half an hour, the cream should be rinsed under running water, and then rinsed hair in a warm vinegar solution (5%). After these procedures, you should wash your hair with shampoo or soap, and start combing the nits (use a frequent comb).

In the process of treatment of the pubic form of pediculosis, the medicine should be rubbed into the abdomen, pubic region, internal femoral surface, and into the groin folds. The effectiveness of the procedure is checked after 24 hours. If necessary, it is worth repeating the treatment.

[26], [27], [28]

Overdose

As a result of an overdose, there may be an increase in adverse reactions (eg, signs of contact dermatitis).

Because of the occasional use of the cream inside or when it is applied in too large a quantity, in addition to the above symptoms, sudden loss of consciousness, delay of the urinary process, and in addition stimulation of the central nervous system (the appearance of seizures, among children) can also occur.

Therapy involves eliminating the symptoms of the disorder. In addition, you need to cleanse the surface of the skin. If the cream has been swallowed, gastric lavage should be performed and activated charcoal should be given to the patient. If necessary, anticonvulsants are also prescribed.

If there is a local allergic reaction to the cream, you need to wash it off the skin with soap and water.

[29], [30], [31], [32], [33]

m.iliveok.com

Share:
No comments

Добавить комментарий

Your e-mail will not be published. All fields are required.

Adblock
detector