Simparica Reviews — ASM Journals

Simparica Reviews

We always start out with the best of intentions, but sometimes we forgot to give our dogs their flea treatments on time. Wouldn’t it be nice if there was a flea treatment that lasts for an extra few days, for those occasions when you forget? There is actually one flea treatment that lasts for 35 days instead of the usual 30: Simparica.

This flea treatment starts working within three hours of being administered, and its effects last longer than most other treatments. This is a great product for dogs that are allergic to flea bites, and dogs with flea allergies have demonstrated significant improvement when they are put on Simparica.

What is Simparica?

Simparica is a flea treatment with sarolaner as its active ingredient, for dogs and puppies six months and older, and weighing more than 2.8 pounds. This ingredient stops the neurotransmitter gamma aminobutyric acid (GABA) receptor from functioning, along with the glutamate receptor, and affects the neuromuscular junction in fleas, which leads to their death. This treatment only needs to be administered once monthly, and if you miss a dose by a few days, your dog will likely still be protected. Simparica can be given orally, or you can crush it up and mix it in with your dog’s food.

Flea Prevention

Simparica not only controls fleas on your dog but also helps to minimize the risk of a flea infestation in your home. It kills fleas before they have a chance to lay any eggs. For the best results, make sure that all pets in the home are treated with an appropriate flea treatment. Simparica is not for cats or other pets, just for dogs, but there are many treatments for all types of pets. When administered for three months consecutively, Simparica can provide a 95.6 percent reduction in adult fleas in the first two weeks, and by the end of the three months, the fleas are completely gone.

Tick Prevention

One of the most widespread health hazards for dogs (and public health hazards) is ticks, so you need to give your dog a medication that prevents both fleas and ticks. Not only can Simparica keep your dog free of fleas, it also kills ticks within eight hours of being administered. Ticks carry deadly diseases, so you will have the peace of mind in knowing that if a tick does get on your dog, it is going to die. Simparica is 96.9 percent effective in keeping ticks away for 35 days. It will eliminate infestations of deer or black-legged ticks, lone star ticks, Gulf Coast ticks, American dog ticks, and brown dog ticks.

Find the Right Simparica for your dog

Benefits of Simparica

When you give Simparica to your dog, you are giving them a full month, and then some, of protection from fleas and ticks. Each tablet provides 35 days of protection, so if you miss a dose for a couple of days, you won’t have to worry about a new infestation. Other benefits of Simparica include:

  • Tasty Treat – These tablets are liver-flavored, and most dogs love them. You can give a tablet to your dog as a treat
  • Easy to Administer – Your dog will likely enjoy eating the tablets, but if not, he will get the same benefits if you crush it up and mix it in with his regular food
  • Weight Categories – This medication is available in six different weight categories: toy, small, medium, large, extra-large, and even larger


When giving Simparica to your dog, it is important to follow the correct dosage, and administer the drug every 30 to 35 days. If your dog is breeding, pregnant, or lactating, talk to your vet before using Simparica. Use the following chart to decide on the correct dosage for your dog:

When administering this medication to your dog, make sure that the entire dose is ingested. Watch your dog for a few minutes after giving them this medication to make sure that it does not spit it out.

Things to be Aware of

This medication is for dogs only, and should not be given to other pets. If you have cats or other pets, talk to your vet about the appropriate flea and tick treatments. Also, this is not meant for human consumption and should be kept well out of the reach of children. Do not use Simparica on dogs that are breeding, pregnant, or lactating, as there are no studies showing if it is safe to do so.

There are some known side effects, which are rare, but that you need to be aware of. Some adverse reactions to Simparica include tremors, decreased awareness of body movement, loss of control over bodily movements, problems blinking, and/or seizures. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment.

If your dog is on any other medications, you don’t have to worry about any negative interactions between Simparica and other drugs. There are no contraindications for using Simparica with other medications.


Not only are fleas and ticks dangerous for your dog, they are also dangerous to humans, and the last thing you want is an infestation of either in your home. Treating your dog with Simparica is safe and easy, and it will ensure that fleas and ticks cannot invade your home and bite you or your family members, as well as other pets.

It is important that you continue to administer treatments monthly in order to make sure that there are no future flea or tick infestations. If you have other pets, make sure that they are also treated, with medications that are meant for them specifically.

Simparica vs. Bravecto: 2020 Comparison and Key Differences

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Simparica vs. Frontline: 2020 Comparison and Key Differences
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Your pets can get fleas from contact with other flea-infested pets, fleas or flea larvae hidden in carpets or pet bedding, or from playing in areas where fleas are present, such as a dog park.

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If your dog is itching from fleas all day, you need to find a medication to relieve the dog’s discomfort and kill the fleas. You may already be giving your dog medication now, but find it’s not working well. There are several types of flea control treatments you can use to stop your dog’s itching.

Flea collars are the most common product to control fleas, and you can buy them at any pet store. Spot treatments, dips, and foggers may be purchased online or at a store, but stronger versions require a prescription. Many pet parents rely on oral medications to treat dogs or cats with flea infestations. These medicines usually require a prescription from your veterinarian.

Oral medications are the easiest to use, and most pets eat the chewable versions just like dog treats.

What to Look for in a Good Flea Treatment

Let’s take a look at the types of flea treatments, what they do, and when you should or shouldn’t use them. Flea treatments need to get rid of adult fleas, and/or flea larvae and pupae. Any product you use, whether it’s a shampoo, dip, a flea collar, or oral medication, should be gentle and non-toxic.

Most dogs can benefit from flea collars, as long as they’re not too invasive. The collar should make adequate contact with your dog’s skin to be effective. Be sure to trim any excess to prevent your dog from chewing on the collar.

Dips are concentrated chemicals that you dip in water. You then pour the solution over the dog’s back or use a sponge to apply it to fur. These solutions last for two weeks and are the most toxic method of flea control. As a result, most vets don’t recommend this method.

Avoid using flea powders, wipes, or foggers, as they aren’t the most effective or modern methods. Sprays and powders can irritate your lungs or your dog’s lungs.

Today’s external treatments, such as topical solutions, are formulated with safe ingredients. Always read product reviews before using any spot treatment, especially if you have a sensitive pet.

Oral medications are prescribed by a veterinarian. You can use chewables alone or with a topical solution. These treatments may be meat or poultry flavored and taste like treats to your pet. Most chewable treat fleas for a month; some treat fleas up to three months.

Simparica vs. Bravecto Similarities

Bravecto is a chewable, pork-flavored tablet for dogs. A study shows that 91 percent of canines happily take the medication. Dogs love the pork flavor and eat tablets like treats. You can administer Bravecto any time, day or night, but it’s best to give him the pork-flavored tablet around feeding time.

Simparica from Zoetis Petcare offers a chewable, liver-flavored tablet that kills fleas. Both medications contain ingredients called neurotoxins to kill fleas. Both products are easy to administer. Many veterinarians have endorsed one or both products. Dogs must be at least six months old to receive either product.

There are no food or drug interactions associated with either product. The reported side effects of both medications include vomiting, diarrhea, lethargy, and decreased appetite.

Both products are sold in color-coded boxes, with the dosage determined by how much the dogs weigh. Smaller dogs receive a smaller dose of the medication. Collies can tolerate both Simparica and Bravecto. (Some brands of chewables are harmful to collies.)

Simparica vs. Bravecto Differences

Bravecto offers pork-flavored flea control chews for dogs, as well as spot, or topical solutions, for canines. Bravecto’s active ingredient is a systemic neurotoxin called Fluralaner. This neurotoxin kills the root of a flea or tick life cycle at the root. It destroys the parasite’s neurological system and stops it from breeding.

Fluralaner destroys new fleas before they lay pupae, and it works for three months after your pet takes Bravecto. Each Bravecto chew lasts 12 weeks. You can purchase one to 500 chews at a time, per your veterinarian’s prescription.

Bravecto can be administered to cats with a spot-on treatment. You apply the topical solution on the area that’s affected. The solution mixes with your cat’s body fluids and is carried to the tissues. The medicine kills the fleas and ticks that stayed alive by relying on your cat’s blood.

Simparica has an active ingredient called Sarolaner. This neurotoxin destroys fleas, ticks, and other insects for 35 days after your dog takes the medicine. Unlike Bravecto, Simparica hasn’t been tested on pregnant, lactating, or breeding dogs. Simparica is only safe for dogs. You can’t use this medication brand on cats, and there’s no topical version.

Simparica vs. Bravecto Pricing Comparison

You can order Simparica or Bravecto online after getting a prescription from your veterinarian, or pick it up in person at a pharmacy. Online sources are usually a better value. The prices quoted below are from, but you can also order online from other sources, such as

Simparica is available in six sizes for dogs only. Each box contains six liver-flavored tablets that treat fleas for one month. The Yellow Box is for dogs 2.8 to 5.5 pounds. This size costs $85, $81 with auto-ship. The Purple Box has medication for dogs weighing 5.6 to 11 pounds and costs $87, $82 for auto-ship.

The Orange Simparica Box is for dogs 11.1 to 22 pounds and costs $88, $84 for auto-ship. The Mint Box is for dogs from 22.1 pounds to 44 pounds. This size costs $95, $91 for auto-ship. The Green Box is for dogs weighing 44.1 pounds to 88 pounds and costs $98, $93 with auto-ship.

The Brown Box is for dogs from 88.1 pounds to 132 pounds. This size costs $99, $94 for auto-ship. Three packs are also available (three month supply), with prices slightly more than half of the prices for six-packs.)

Bravecto offers chews and topical solutions for dogs, as well as topical flea control for cats. You can purchase from one to 500 chews in your dog’s weight/size. The Yellow Box, for dogs weighing 4.4 to 9.9 pounds, costs $54 for one chew ( three months), or 108.76 for two chews (six months).

Larger sizes have a comparable price difference when you match them up with Simparica.

We recommend Bravecto since you can customize the number of chews depending on your dog’s condition. Each Bravecto chew lasts three months compared to one month for each Simparica. You can also purchase topical solutions for dogs and cats from Bravecto.

Our Review of Simparica vs. Bravecto

Bravecto and Simparica both work fast to get rid of fleas and ticks. One dose of Bravecto works in two hours on fleas and can control them totally within eight hours. This medication controls ticks within 24 hours. Simparica works within three hours on fleas and in eight hours on other insects.


Bravecto is the best choice if you want to simplify your dog’s flea and tick care routine. One dose guards your dog against fleas and ticks for three months. If you want a monthly medication, choose Simparica.

Some pets fare better with topical solutions instead of chewables. Simparica only offers chewables. Bravecto has six topical solutions for dogs by weight/size. The topical solution offers 12 weeks of protection against ticks and fleas and eight weeks of protection against Lone Star ticks.

Bravecto also gives you six topical solution choices for cats – three flea and tick choices, by cat weight, and three Bravecto Plus solutions, also by cat weight, which treat heartworms and intestinal parasites as well as fleas/ticks.

Both products are well-tolerated by most dogs, although there are a few minor side effects reported by some pet parents. Bravecto stays in your dog’s bloodstream for quite a while, so you’ll get your money’s worth with this medication. If your vet recommends it, you can also use the topical version of Bravecto with the chewable for severe cases of fleas/ticks.


Simparica is a relatively new product, so we don’t have a lot of studies on this drug, or many owner testimonials. It kills ticks as well as fleas. One study shows that this medication is 96.9 percent in preventing brown dog ticks, deer ticks, Gulf Coast ticks, Lone star ticks, and American dog ticks.

This chewable tablet controls fleas on dogs by killing them before they lay eggs. You should treat all dogs in your home with this medication to prevent fleas from spreading.

Overall, Bravecto offers the most bang for your buck and enough choices to cover most flea infestations in your dog and/or cat.

Flea Treatment FAQs

Can a pregnant or nursing dog take oral medications for fleas?

It depends on the brand. Some medications are safe for pregnant/nursing dogs, while others have no conclusive evidence as to their effect. Simparica hasn’t been evaluated for its safety on pregnant, lactating, or breeding dogs. However, Bravecto is approved for use in pregnant, breeding and lactating dogs.

Can you crumble up chewables and put them in your dog’s food?

You can crumble most oral medications chewable and put them in your dog’s food, but be sure he eats the entire chewable. Giving your dog the chewable as a treat is easier and more efficient since chewables are flavored.

Do oral medications kill fleas that are already on my dog?

Check with the manufacturer to make sure oral medications destroy fleas already on your dog’s fur. Some brands are made to destroy larvae and pupae, while others kill adult fleas. Some brands kill adult fleas, larvae, and pupae.

What’s the best way to manage and prevent fleas?

Use a monthly treatment, whether it’s an oral medication or a flea collar. Use another method if your vet recommends it. Keep your dog’s coat clean and brushed. Bathe your pet regularly to keep him clean and prevent the conditions that encourage pests.


Although Simparica and Bravecto are both recommended by veterinarians, we choose Bravecto as the better value and most effective flea treatment of the two brands.

Bravecto costs more than Simparica, but it gives your pet longer and better protection against fleas and ticks. You can choose the exact number of chewables you need, from one to 500 on (You’ll need to ask about available quantities if you order from other sources.)

The company also makes topical solutions you can use alone or with chewables – you don’t get that choice with Simparica, which only comes in chewables. Bravecto also offers topical solutions for cats.

Based on expert reviews and our research, Bravecto gets our recommendation over Simparica. Bravecto has been on the market longer, and research shows that 93 percent of pet parents whose dogs spend 12 hours or more daily outside prefer to use Bravecto over other flea and tick treatments.

Toss chewables in with dog treats if your dog is playful and likes to run after treats, or mix treats in with his dry food. Either way, most dogs will enjoy eating these pork-flavored chewables.

Remember to avoid feeding your dog any new food or treats when you introduce Bravecto to his regimen. In the unlikely event, he has a reaction, you’ll know it’s the chewable, and not something else.

You’ll save time by giving your dog one chewable every three months instead of once a month. Bravecto works on new fleas, so it gets rid of moderate to severe infestations quickly. If you would rather keep a monthly schedule, you might prefer Simparica, but this schedule preference is the only reason for you to use Simparica over Bravecto.

Always talk to your vet before deciding on a flea treatment plan. What’s suitable for one dog might not work for another. You need to think about the extent of the flea infestation, your dog’s temperament, and weight, and what other medications he takes, if any.

Petition for the immediate withdrawal of Simparica (flea & tick treatment) from the market

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Controversial tick and flea «remedies» Nexgard and Bravecto were both approved and released in late 2013 and early 2014 respectively. Ever since, the controversy around these products has been increasing on a continuous basis. Both of these drugs already have quite an impressive legacy of suspicion of causing extremely serious adverse reactions, including the death of several hundred of innocent Canine victims.

March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick “remedy”… and already several dogs have been adversely affected by this new drug.

It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is concerning. The 26 reported cases stated have occurred between the release date March 2016 and Jul 2016. Considering the fact that the drug had by Jul 2016 only been on the market for 4 months, this is very good reason to doubt the safety of this drug. In view of what had already been reported for its two sister drugs, it would be fair to assume that Simparica is going the same way.

These drugs are supposed to protect our pets by killing the pests that invade the lives of animals. At least that part of the promise holds true: they are deadly to ticks and fleas.

If it ended there, and the quality of our pets’ lives were improved by these so-called “remedies”, they would have been welcomed with open arms. but it doesn’t end with killing the pests; numerous side effects have been experienced by many beloved pets and reported by their owners, including severe gastritis, vomiting, bloody diarrhea, seizures and even several deaths. Many dogs died after having ingested an Isoxazoline drug.

In spite of numerous calls to Merial, Merck and the FDA and lately also to Zoetis, the manufacturer of Simarica, our problem seems to be ignored. And now, after the sad passing of Cuddles, the very dear and beloved Canine friend of Susan Rae, following a dose of Simparica, I feel that it is time to take action. Please read the posts on this public Facebook group:

The story of Cuddles by Susan Rae:

While she was still alive, after the drug was administered:

“I spent the entire day at the Emergency Veterinary Clinic. My Baby has liver disease and acute pancreatitis. Cuddles is with me 24/7 since I am currently homebound. I really miss having her with me. She has to stay in the hospital for a few days and can come home if things go ok. I am so sad and depressed. I have been crying all day. I love that little dog”

After the sad event of her passing:

“I want to thank you for adding me to your group. I just wish I would have known about this a couple weeks ago. Through research I have found that Simparica, Bravecto, and Nexguard all have one thing in common, they kill dogs! We had to put our sweet, sweet Cuddles to sleep a week ago. She was a little, precious toy poodle. Our Vet called Cuddles a miracle dog. She was 15 1/2 and probably would have lived a few more years if I had not given her Simparica. Throughout her life Cuddles had liver disease, Cushing disease, pancreatitis, and the last few years, some kidney problems. Although she was not in kidney failure. She was on medication for all of these diseases and I gave her the best medical care possibly. The is why she lived so long. Cuddles had NEVER had fleas in her life. She was licking so I took her to the vets. Her bowels and blood test came out fine. Her kidneys and liver had even improved, but she did have fleas. He gave me a free sample of Simparica and told me to give her one that afternoon. I gave it to her at 4 and by 6 she had diarrhea. Later that evening she had pure blood coming out of her with dry heaves. Then the tremors started. I had to take her to the emergency clinic. Total waste of time. My vets the next day. He didn’t think it was from the pill. She got worse and we were up with her all night. She was bleeding to death internally, vomiting, tremors, unsteady, would fall when she would try to walk, salivating. Would lean against the wall and hang her head down. It broke my heart to see the pain I put her through by giving her Simparica. We put her to sleep early that morning. I am having a very hard time forgiving myself and don’t know if I ever will. Please do not give your dog any of these pills. Cuddles was fine and tests were great that morning. Thank you for letting me share this awful time in my life. I hope it will help save another dog’s life.”

Here is a link to the combined ADE report for Bravecto, Nexgard and Simparica:

Here are links to articles by two well-known holistic veterinarians on these three drugs:

After reading the story of Cuddles as posted directly from Susan Rae’s Facebook profile, as well as the attached ADE report and the two articles on the safety of the Isoxazoline drugs, please decide for yourself. Is a third Isoxazoline drug really necessary while the two older ones have not even been proven beyond doubt to be safe for our furkids?

And then please do the right thing by signing this petition. We need this drug, and the other two, to be withdrawn from the veterinary scene with immediate effect. And we need them to stay off the market. Our dogs do not need these drugs, as there are other much safer methods to combat the problems that these drugs are supposed to combat but are in fact aggravating because of the horrible side effects.

Your dog can still contract a tick borne disease because the drugs don’t even repel the parasites. They have to bite and attach to the dog and take a toxic blood meal off the victim in order to die…

Simparica for Dogs Cost, Side effects, Reviews, Safety

Learn all about Simparica for dogs cost, side effects, reviews and safety. Simparica (sarolaner) was just introduced in March 2016.

It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma Americanism (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly and requires a prescription from your veterinarian.

Simparica orally administered flea and tick treatment for dog is a monthly treatment that can be given with or without the food. One chewable tablet per month is enough to treat and protect your dog against flea infestation and to control the tick infestation. Simparica contains the active ingredient Sarolaner, which inhibits the function of the neurotransmitter gamma amino butyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular spot in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. It is easy and safe to administer, by directly giving it into the dog’s mouth or mixing it with food for rapidly killing the fleas and ticks.

The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception (awareness of body position and movement), ataxia (loss of full control of bodily movements), decreased or absent menace blinking reflex or seizures.

Sarolaner was safe, achieved 100% reduction in the numbers of S. scabiei detected and resulted in marked improvement of the clinical signs of sarcoptic mange in dogs following two monthly oral administrations.

Simparica for Dogs

Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. Simparica (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month.

Simparica Cost

Simparica is orally administered to dog that are 6 months of age or older and weighing more than 2.8lbs. Available in six different packs categorized as per the dog’s body weight, the chewable are suitable for all breeds and sizes of dogs. Simparica costs are according to weight and the pack size. The prices are listed below;

Simparica Chewables for Dogs 11.1-22 lbs (Brown)
3 Pack is of $34.13
6 Pack is of $58.93

Simparica Chewables for Dogs 2.8-5.5 lbs (Yellow)
3 Pack is of $31.14
6 Pack is of $52.34

Simparica Chewables for Dogs 5.6-11 lbs (Purple)
3 Pack is of $33.15
6 Pack is of $55.36

Simparica Chewables for Dogs 22.1-44 lbs (Blue)
3 Pack is of $36.13
6 Pack is of $60.38

Simparica Chewables for Dogs 44.1-88 lbs (Green)
3 Pack is of $38.07
6 Pack is of $62.36

Simparica Chewables for Dogs above 88 lbs (Red)
3 Pack is of $39.79
6 Pack is of $68.42

Simparica Side effects

Every drug has side effects. Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. The most frequently reported adverse reactions were vomiting and diarrhea.

Simparica Reviews

Simparica is effective against fleas and ticks, even on day. You can count on Simparica to do the following:

  • Provide rapid relief for pets with existing flea infestations, even dogs with flea allergies
  • Improve clinical signs of flea allergies in dogs by eliminating fleas
  • Prevent and control home flea infestations, killing fleas before they can lay eggs
    Some reviews are listed below;
  • Quickly kill ticks, which may help reduce the risk of potentially life-threatening flea- and tick-borne diseases. One says, “It is a great product. I love how easy it is to give and that it covers my dog for fleas, ticks, mange and mites. My dog loved the tablet and thought she was getting a treat which is fantastic. This will be a regular purchase for our girl’’.
  • One other review, “Usually I have to cover tablets with something tasty. Or crush them up and add them to his feed, but with the simparica chews it swallowed them straight away. I found them very effective, and the pooches had no nasty reactions to the chew which was a big sigh of relief’’.

Simparica Safety

Simparica efficacy and safety of a novel isoxazoline compound, sarolaner and spinosad as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Sarolaner administered orally to provide a minimum dosage of 2.0 mg/kg (range 2–4 mg/kg) once monthly for three consecutive treatments was safe and effective in the treatment and prevention of natural infestations of fleas and resulted in a substantial improvement of clinical signs associated with FAD.

12 thoughts on “ Simparica for Dogs Cost, Side effects, Reviews, Safety ”

We gave our Austrailian Cattle Dog 1 dose of Simparica. We noticed he was seeing well the next day and within 24 hours he was blind.

was the blindness ever connected to the simpatico?

are you certain it was the Simpatico?? Could it have been something else?? Also what made you determine it was the flea medication?

Status of your dog after @1 year?
Was blindness temporary?

I gave my 7 month old BRT Simparica 1st treatment on July 1st. On July 2nd she had diarrhea, she’s a puppy, I figured she ate something the way Puppies can and with brief fast, chicken and rice etc the loose stools cleared up within a week.
I mentioned it to my Vet, he said bland diet let me know how she goes. (I did mention the timing questioning the Simparica).
Aug 1st 2nd simparaca dose. That night woke me up with diarrhea. Thru the night thru the day. I called my Vet again he suggested fast bland diet let’s see.
4 days no improvement, he said she probably got into something at the dog show and prescribed metronidazole. Disregard cleared up in three days, I finished the 7 day prescription. Vet expressed no concerns re Simparica.
Against my better judgement, 9/1 3rd dose of Simparica – that next morning 5am pup had raging liquid diarrhea. I called Vet and brought in stool sample per his request, still no response to the “coincidence” of 3 months in a row of having bad diarrhea within 24 hours of Simparica.
Her fecal Test shows exposure to giardia but not active. He prescribed 7 day dose of Panacur.
9/13, still on rice and boiled chicken, still waiting for normal bowel movements to start switching her diet. She starts to firm up then breaks w diarrhea. On 9/10 overnight and thru 9/11 she had the WORST diarrhea I’ve ever seen from a dog. Still Vet said get her thru the Panacur then let’s see how she’s doing.
9/12 1:30 was last bout of liquid stools. All thru this her attitude has been normal happy puppy. She’s drinking water, not as much as her normal and I give her 25mls by mouth thru the day she also will drink from a water bottle so I feel comfortable about her water intake. 9/15, we skipped the dog show this weekend. I don’t want to add ANY stress to her system as she SEEMS to be on the road to recovery despite only 2 bm yesterday, at noon – normal. At 5 – ploppy.
Since then nothing. She is 9 months old, a giant breed puppy who now weighs 61.9 pounds. She should be 80 and she is malnourished at this point. As she improves her compromised development will need to be addressed. I believe in slow growth but am panicked now that she hasn’t been able to absorb the nutrients she needs for healthy bone developemnet.
Talk me down people!! I love my dog, she is SO SO SWEET.
I LOVE my Vet, and trust him. But now I’ve checked on simpiraca and feel absolutely STUPID for not checking WHEN IT WAS PRESCRIBED. And shocked that my Vet has glossed over even the remotest possibility that this particular puppy just might not be able to tolerate this DRUG. (I DOUBT strongly that this puppy needed the Panacur). I’ve never used an ingestable flea POISON before and I NEVER will again.
Why are vets willing to prescribe it?

Omg I been going through the same thing

We gave our toy poodle puppy and toy poodle girl
Simparica they have been off their food since.
Today is day five. They are doing mucus runny poos and my adult poodle now has blood in her poo

Gave my rescue girl this last week. Now instead of solid stools they are watery.

There is a video on Facebook everyone who is thinking of using Simparica should see. Uncontrollable seizures in a dog….just horrific to see this dog and what he is going through while his owner is trying to comfort him. He will now have this side effect for the rest of his life. Think long and hard before using this.

Simparica is known to cause seizures and other neurological problems which may be permanent. This product should be off the market. DO NOT USE SIMPARICA on any animal.

My 7 month old male Goldendoodle developed vomiting of digested blood 4 days after Simparica and the following day developed black tar like stools of digested blood. He has had a barium series that showed no foreign bodies and endoscopy which showed hemorrhages in the stomach and upper bowel. The biopsy report is pending. He has been on metronidazole and then tylan powder along with peptobismol and omeprazole and a bland diet which he hates. It is now day 18 since his last dose of Simparica and he looks good on the outside but has a very selective appetite and has dark black watery diarrhea still but now with some red blood in the stool. His intestines are still bleeding and he is not responding to therapy that should have resolved the diarrhea by now. I am a Veterinarian and have not seen this in over 45 years of practice. I have consulted with Veterinarian gastroenterologist and MD gastroenterologist and they have no answers. The big question is. How long does Simparica stay in the dogs system at a toxic blood level if they are sensitive to the drug?

I am very distressed now. I gave my dog a single dose of Simparica today. He was with other dogs on the weekend and I found a flea on him yesterday (Monday). I asked the vet what they recommended. I stressed that I dislike putting toxins in my dogs body. They recommended Simparica, I asked if they had experienced any negative side effects. I was told that this product is perfectly safe. I won’t be able to sleep tonight after what I have just read.

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