Celandine: instructions for use of the drug

Celandine: instructions for use of the drug

How to use celandine: instructions for use

Not always for the treatment of various diseases it is possible to use traditional medicines. Often enough for medical therapy uses recipes medicinal products based on medicinal herbs. Especially often resorted to the use of such medicinal plants as celandine. This component is often used to prepare various medicines, decoctions, tinctures, ointments. It helps to reduce inflammation, relieve pain and other unpleasant consequences. But instruction on the use of celandine is recommended to study properties of this plant in more detail, because it has contraindications.

Description celandine

Celandine is a herbaceous perennial plant, which belongs to the family poppy. In height can reach up to 70 cm, and sometimes more. The celandine looks like this:

  • short rhizome;
  • root outside has a branching stem with a reddish-brown tint, and the inside of the fork is painted in a yellow-orange color;
  • on top of the stems are ridged, erect and branched, bottom bare and branchy;
  • pinnate leaves, which are bottom painted in gray shade. The lower part of the leaves is considered to be sedentary, growing on thin stalks that also have healing properties. The shape of the leaves of celandine are similar to maple leaves, but the difference is that in the leaves of celandine are smooth edges;
  • the flowers are bright yellow, collected in inflorescence-umbrellas for 7-8 pieces, which are arranged with the edges of the stems.

The composition of celandine

Plant celandine has a lot of nutrients. The main part of useful components contained in the milky juice that outdoors is quickly becoming orange.

Juice of celandine contains in its composition of alkaloids isoquinoline group:

  • chelidonine. This component on its structure resembles morphine and papaverine;
  • homochelidonine. This component is a convulsive poison, but it is a good anesthetic agent;
  • sanguinarin. This substance improves intestinal peristalsis and stimulates the process of salivation;
  • chelerythrine – has a local irritating effect;
  • protopin – this component reduces the reactivity of the autonomic system.

In addition to the above components, the composition of this plant the plant has many vitamins and minerals: organic acids, ascorbic acid, saponins, carotenoids, essential oils.

Pharmacological properties

Celandine has long been known for its unique properties due to which it is widely used to remedy various diseases.

The plant has beneficial effects for different ailments:

  • it has a cauterizing effect, so it is actively used to eliminate calluses, polyps, slingshot, papillomas;
  • quickly reduces inflammation;
  • it has wound-healing effect;
  • has antispasmodic effect;
  • has antipruritic properties;
  • antifungal, and antimicrobial action;
  • dermoprotective properties.

Under what indications it is recommended to apply preparations on the basis of celandine

The use of celandine helps in the elimination of many diseases. Importantly, it should be used according to the instructions. This ingredient and drugs based on it have a wide range of influences. It is used for the treatment of diseases such as:

  1. Ulcers of various locations.
  2. To eliminate deposits of sand in the gall bladder and the kidneys.
  3. Celandine is frequently used for menstrual disorders, as well as in various gynecological pathologies.
  4. For treatment of trophic ulcers and various skin conditions – eczema, warts, HPV, scabies, dermatitis, the formation of psoriasis and wounds.

Under what indications do not use

This plant is contraindicated in:

  • seizures;
  • angina;
  • asthma;
  • not recommended for children under 5 years.

Use is contraindicated for women during pregnancy and breastfeeding. Components of the plant can cause unpleasant symptoms, so it is best to women in this period to refuse the application.

Application features

It is important to know how to apply the celandine, tinctures and preparations based on it. You should pay attention to the General guidelines for the use of drugs with celandine:

  • celandine tincture is prepared as follows: to 1 Cup of water filled with 2 large scoops collect celandine. It should be prepared in a water bath, the mixture is filtered and brought to 200 ml Infused for days. Should take 1/3 Cup three times a day, 15 minutes before eating;
  • can be used as a lotion or cleanser. In the bathroom with hot water, pour two cups of infusion of celandine. The resulting solution to warm up about 15-20 minutes more;
  • the tincture can be used for local douches, helps to eliminate various gynecological and urological pathology;
  • is used as enema. In these cases, it is used to cleanse the bowel, for hemorrhoids, polyposis of the colon. Use a solution of 10 grams of tinctures, you need 100 grams of water. Half a litre of water is added to 50 ml of infusion. The treatment period can last from 10 to 20 days. Enemas can be done every day or every other day.

It is not recommended to self-medicate. First you need to consult a doctor who will help to establish an accurate diagnosis and prescribe the appropriate treatment regimen.

Prescription medications based on celandine

On the basis of celandine, can make various home remedies that will help eliminate many diseases. Most importantly, you need to prepare funds on the basis of this plant and to know the peculiarities of their application.

The tincture recipe with the juice

A good action has a home agent based on vodka and celandine. It is usually used to eliminate warts, papillomas, corns, periodontal disease, polyps, and can also be used for the treatment of benign prostatic hyperplasia in men.

Peculiarities of preparation and use:

  • you need to mix 50 grams of vodka and 100 ml of the juice of celandine;
  • the ready mix is recommended to take 1 drop a day, every day the dosage need to increase;
  • the maximum dose should be 30 drops;
  • it is recommended to take on an empty stomach. It on an empty stomach there is a good absorption of active compounds in the slime layer, and they quickly penetrate into the blood;
  • as soon as the dose reaches 30 drops, medical therapy should end;

Recipe broth

Broth is often used to treat skin diseases, eczema, rashes on the skin surface.

How to make and use:

  1. In a container sprinkle 1-1,5 big spoons of dry collection of celandine.
  2. Next, pour 500 ml of hot water.
  3. Put the tank on fire and boil on low heat for about 10 minutes.
  4. Next, remove from heat, drain.
  5. The mixture should stand for 3 hours.
  6. In the morning and evening time you need to take half a Cup of broth.
  7. The average period of treatment should be 10 to 14 days.
  8. Can be used for lotions. In these cases, a stronger mixture to 1 Cup and added 1 large spoon of the herb.


An ointment of the juice of celandine is used to treat acne, pimples. Prepare the cream by oneself.

Peculiarities of preparation and use:

  • you have to mix the juice of the plant and vaseline in the proportion of 5:1;
  • the finished ointment should be applied to the skin in the evening;
  • after 15 or 20 minutes the face can be rinsed;
  • the usage period from 10 to 14 days.

Side effects

To use these tools correctly, otherwise it can cause unpleasant side effects. Sometimes overdose during internal use can appear respiratory paralysis.

Among the side symptoms may be:

  • diarrhea;
  • nausea;
  • retching;
  • the state of dysbiosis.

Pharmacy release form

Celandine in the drugstore can appear in different forms, but each form has the same composition and has the same effect.

Possible forms of sales:

  1. Dry collection.
  2. Powder.
  3. Tincture of celandine.
  4. Ointment.
  5. Celandine liquid in the form of oil and juice.

Also at the pharmacy you can find celandine in ampoules. Liquid can be used in papillomas, warts, calluses and other formations on the skin.


This form is available in the form of a liquid, which has the infusion, potassium and sodium lye. Is used to eliminate warts, calluses, warts.

In the processing of the fluid caused necrosis of the skin, which die quickly from the effects of chemical components. Therefore, affected cells die off quickly, and the formation disappears.

Made in small bottle, which is similar to perfume. Inside the bottle there is a solution of celandine, which is applied with a special applicator.

Application of superchatel:

  • before using the skin around the education, growth should be treated with a thick layer of any cream with moisturizing structure. This will protect the skin from chemical burns;
  • in papillomas and warts apply one drop to education once a day. Is applied from 1 to 3 days, depending on the size of the papillomas. After 7-10 days you need to check on the status of education if they were not, the treatment is again repeated;
  • while molluscum contagiosum will apply 1 drop, period of treatment – 1 day;
  • when dry calluses on education should be applied one or two drops of liquid celandine. Time medical therapy needs to be about 10 days.

It is not necessary to use this form of celandine for children under 5 years and women in the period of carrying a child. Not recommended for treatments on the face, mucous membranes and genitals.

Pencil warts with celandine

In the pharmacies you can face another shape against the of papillomas, warts, corns and growths of different formations. Pencil contains extract of celandine, it has only a alkaline solution and a special dye.

The use of this form is quite simple:

  1. To apply the medicine should point to the area of growth.
  2. Areas around education should be lubricated moisturizing cream that protects the skin from chemical burns.
  3. After applying there will be a darkening of the wart and its subsequent exfoliation.
  4. The treatment period can range from 3 to 5 days, it all depends on the extent and amount of education.

If desired, the pencil celandine can be done independently. To do this, a small amount of dried celandine grind into powder and mix with pork fat. Next, the resulting mixture should be given a conical shape. The pencil retracts into the freezer until fully cured. Ready pencil can be used for treatment of papillomas, warts, corns and different formations.

Form for Pets – «Works Plus»

In many pharmacies you can find interesting product for Pets – collar «Works Plus». The collar helps to eliminate fleas, vlasiadou and other nasty parasites, which cause severe discomfort to the animals.

As active substance the collar contains diazinon 10%. There are also auxiliary components – phthalate, chalk, calcium stearate, tribasic lead sulfate and titanium dioxide.

In appearance this product is made in the form of a polymeric tape of black color, a retainer. For dogs collar length is about 65 cm, for cats 35 to 40 cm.

This form is recommended for continuous wear. Usually against ticks collar is recommended to be worn for approximately three months, from other types of parasites – 4 months.

Celandine is a unique herb that helps eliminate many ailments. But before to use it, should carefully study all its properties, composition and usage. Need to know how to apply this plant and in what dosages.


Amoxicillin instructions for use

Description relevant to 03.09.2015

  • Latin name: Amoxicillin
  • ATH code: J01CA04
  • Active substance: Amoxicillin (Amoxicillin)
  • Manufacturer: Biochemist, AVVA-RUS, Barnaul plant of medical preparations, Organika, Dalkharmharm, STI-MED-SORB (Russia), Natur Produkt Europe B.V. (Netherlands), Hemofarm (Serbia)

The capsule contains the active ingredient. amoxicillin (as part of the drug in the form of trihydrate). A similar active substance is in the composition of the tablets, as well as granules, from which Amoxicillin suspension is prepared.

pharmachologic effect

Amoxicillin is an antibiotic that has a wide range of effects. Antibiotic group — semi-synthetic penicillins. Annotation indicates that the drug is a 4-hydroxyl analog ampicillin. Provides bactericidal effect. Demonstrates activity against aerobic gram-positive bacteria, namely Streptococcus spp., Staphylococcus spp. (except for those strains that produce penicillinase). Also active against aerobic gram-negative bacteria: Shigella spp., Neisseria gonorrhoeae, Escherichia coli, Neisseria meningitidis, Klebsiella spp., Salmonella spp.

Pharmacokinetics and pharmacodynamics

Amoxicillin trihydrate very quickly and completely absorbed from the digestive tract, while the acidic environment of the stomach is not destroyed. The maximum level of concentration of a substance in the blood is noted 1-2 hours after taking the drug. If you double the dose of the drug, similarly, twice, the concentration increases. If there is food in the stomach, the total absorption does not decrease. If amoxicillin is administered in / in or in / m, similar concentrations of the active substance are noted in the blood. The substance is bound to plasma proteins by about 20%. In the body, the active substance is distributed in fluids and tissues. In the liver, the presence of large concentrations of the active substance.

Plasma half-life is 1–1.5 hours. Approximately 60% of the dose taken orally is excreted from the body. Displayed unchanged. A certain amount of the substance is also in the feces. A longer half-life is observed in the elderly and newborns.

In small quantities, is able to penetrate the BBB during inflammatory processes of the pia mater.


It should be noted that the following contraindications to the use of this drug are noted:

  • severe infectious diseases of the digestive tract, in which the patient suffers diarrhea, vomit,
  • Infectious mononucleosis,
  • lymphocytic leukemia,
  • allergic diathesis,
  • viral respiratory infections
  • hay fever,
  • bronchial asthma,
  • high sensitivity to cephalosporins, penicillin.

Use drugs with metronidazole not in the following cases:

  • in diseases of the nervous system,
  • for blood disorders,
  • at infectious mononucleosis and lymphocytic leukemia,
  • with severe sensitivity to derivatives nitroimidazole.

Drugs with clavulanic acid can not be used for jaundice and abnormal liver function in history.

Side effects

In the course of treatment with this drug, the following side effects may occur:

  • manifestations associated with allergic reaction of the body: Quincke’s edema, erythema, hives, conjunctivitis, rhinitisin rare cases joint pain, eosinophilia, fever, and very rare anaphylactic shock,
  • manifestations — a consequence chemotherapeutic effect: the development of superinfections, which are most often manifested in people suffering from chronic illnesses, and those who have decreased resistance,
  • symptoms are a consequence of prolonged use of funds in high doses: ataxia, dizziness, depression, disturbances of consciousness, convulsions, peripheral neuropathy, therefore, how many days the agent should be taken, only the doctor should determine
  • at combination «amoxicillin, metronidazole»: vomiting, nausea, constipation, anorexia, diarrhea, stomatitisepigastric pain, glossitis, in rare cases, pseudomembranous colitis, hepatitis, allergic manifestations, impaired hematopoiesis, interstitial nephritis,
  • at combinations «amoxicillin, clavulanic acid»: hepatitis, cholestatic jaundicein rare cases — erythema multiformeexfoliative dermatitis, toxic epidermal necrolysis.


As a rule, overdose does not show a pronounced toxic effect, even if a large dose of the drug was taken. If a large dose of Amoxicillin was taken, the patient has symptoms of a gastrointestinal disorder, a violation of water and electrolyte balance. In people who suffer from renal insufficiency, overdose may show signs of nephrotoxicity and crystalluria.

Symptomatic treatment is carried out, for which the medicine prescribed by the doctor is used, should also be taken. Activated carbon. May apply hemodialysis. There is no specific antidote.


Wikipedia suggests that the drug may reduce the effectiveness of oral contraceptives.

If taken simultaneously with bactericidal antibiotics, the patient notes synergismif taken simultaneously with bacteriostatic antibiotics, manifests itself antagonism.

The drug stimulates the effects of indirect anticoagulants, reduces the prothrombin index and the synthesis of vitamin K.

Reduces the effectiveness of drugs, in the process of metabolism which manifests PABK.

Tubular secretion is reduced allopurinoldiuretics probenecid, phenylbutazone, NPVS. As a consequence, it is possible to increase its concentration in the blood.

Under influence ascorbic acid Amoxicillin absorption increases, and when taken simultaneously with glucosamine, antacids, aminoglycosides, laxative drugs — decreases.

If the simultaneous use of amoxicillin preparations, clavulanic acid, is practiced, there is no change in the pharmacokinetics of these drugs.

Microorganisms that produce penicillinase show resistance to the basic substance.

When combined with metronidazole, it is relatively active Helicobacter pylori.

There is cross-resistance between amoxicillin and ampicillin.

special instructions

Amoxicillin as well Amoxicillin Clavulanate and other varieties of the drug should be carefully taken to people who are prone to allergic manifestations.

Do not take the drug with metronidazole for people who suffer liver diseasesas well as those who have not yet turned 18 years old.

Cross-allergy may occur in people who have an increased sensitivity to carbapenemam, cephalosporins.

Keep in mind what helps Amoxicillin. Thus, the drug is ineffective in the treatment of acute respiratory viral infections.

If the patient has a sign of severe gastrointestinal infections with manifestations of diarrhea, vomiting, then tablets should not be prescribed due to poor absorption.

Caution drug should be used to people with bronchial asthma, allergic diathesis, hay fever.

If the patient is forced to take the drug for a long time, he is additionally prescribed Levorin, Nystatin or other antifungal agents.

It is important to monitor the condition of the kidneys, liver, as well as laboratory indicators of urine and blood in people who take large doses of the drug for a long time.

Patients who ask the doctor questions about whether Amoxicillin is an antibiotic or not, should take into account that this tool is an antibiotic, so it is advisable to always consult a doctor before starting his reception. It is the doctor who determines how many days to take the medicine, as well as its dosage. You should not decide on what Amoxicillin tablets helps, and practice self-medication.

The drug for cats, dogs and other animals should be used only after the appointment, which holds a veterinarian.

Amoxicillin combination omeprazole, clarithromycin used for the treatment of peptic ulcer.


Penicillin semisynthetic drug. The mechanism of action of this drug is based on its ability to specifically inhibit peptoglycans (bacterial cell membrane enzymes), which leads to cell death and dissolution.

Amoxicillin is active against:

Gram-positive aerobic bacteria — Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Listeria monocytogenes, Enterococcus faecalis, Corynebacterium spp. (except Corynebacterium jeikeium), Bacillus anthracis.

Gram-negative aerobic bacteria — Escherichia coli, Helicobacter pylori, Borrelia sp., Salmonella spp., Shigella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp., Neisseria spp.

Others — Chlamydia spp., Clostridium spp., Peptostreptococcus spp., Bacteroides melaninogenicus, Fusobacterium spp.

Indications for use

  • Bacterial diarrhea, dysentery and other intestinal pathologies of infectious origin,
  • Otitis media and external otitis media of unspecified etiology,
  • Acute and subacute endocarditis,
  • Acute respiratory infections
  • Sinusitis (acute form)
  • Pharyngitis of unspecified etiology,
  • Chronical bronchitis,
  • Pneumonia,
  • Cystitis,
  • Infections of urogenital organs without specified localization.

Dosage regimen is purely individual. The single dose for adults and children over 10 years old, with a body weight exceeding 40 kg, is 250-500 mg. In severe forms of the disease — up to 1 gram.

For children up to 2 years old, a single daily dose is 20 mg / kg.

Children from 5 to 10 years old — 125 mg.

The interval between doses of the drug — 8 hours. In patients with impaired renal function, the interval is increased to 12-24 hours.

Drug interactions

With simultaneous use of Amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed, and when taken together with ascorbic acid, metabolism increases.

Drugs that block tubular secretion, cause an increase in Amoxicillin, while the use of Methotrexate increases the toxicity of the latter.

When used concurrently with metronidazole, nausea, vomiting, diarrhea, and epigastric pain often develop.

In a complex with clavulanic acid, the development of cholestatic jaundice, hepatitis, and multiforme erythema is possible.

It is strongly contraindicated for simultaneous use with disulfiram. Special care should be taken when using Amoxicillin and anticoagulants at the same time (this may cause prolongation of prothrombin time.

Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amoxicillin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.

Pharmacy sales terms

It is released on prescription.

How much is Amoxicillin? The cost of pills is low. 250 mg tablets will cost 35-50 rubles (20 pcs.). Capsules are a bit more expensive — about 100 rubles. Granules have about the same cost as capsules. Price depends on the manufacturer. The cheapest tablets produced by Avva Rus.

Release form and composition

Available in different forms: tablets, capsules with powder inside. There are also in the form of granules used to prepare the suspension. The main active ingredient is amoxicillin in the form of trihydrate. Excipients: polyvidone, magnesium stearate, talc, sodium carboxymethyl starch, titanium dioxide and hypromellose.

The drug is produced by several companies at once:

  • Biochemist,
  • Hemofarm (Serbia),
  • Natur Produkt Europe B.V. (Netherlands),
  • Barnaul plant of medical preparations,
  • Darchharm,
  • Organic,
  • STI-MED-SORB (Russia).

The semi-synthetic drug from the penicillin group is packed in cardboard. The tablets are oval or oblong with notches on both sides. Capsules have 250 and 500 mg. In one pack of 16 pieces. The granules are immediately in the bottle. The introduction of antibiotics by injection is not provided.

Pharmacological effect

Penicillin semisynthetic drug. The mechanism of action of this drug is based on its ability to specifically inhibit peptoglycans (bacterial cell membrane enzymes), which leads to cell death and dissolution.

Amoxicillin is active against:

Gram-positive aerobic bacteria — Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Listeria monocytogenes, Enterococcus faecalis, Corynebacterium spp. (except Corynebacterium jeikeium), Bacillus anthracis.

Gram-negative aerobic bacteria — Escherichia coli, Helicobacter pylori, Borrelia sp., Salmonella spp., Shigella spp., Campylobacter, Haemophilus spp., Proteus mirabilis, Leptospira spp., Neisseria spp.

Others — Chlamydia spp., Clostridium spp., Peptostreptococcus spp., Bacteroides melaninogenicus, Fusobacterium spp.

Use during pregnancy and lactation

Amoxicillin penetrates the placental barrier, in small quantities excreted in breast milk.

If you need to use amoxicillin during pregnancy, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus.

To use amoxicillin with caution during lactation (breastfeeding)

Side effects

When using Amoxicillin, the following side reactions are possible:

  • Allergic reactions: erythema, urticaria, skin flushing, rhinitis, conjunctivitis, angioedema, rarely — joint pain, fever, exfoliative dermatitis, Stevens-Johnson syndrome, very rarely — anaphylactic shock,
  • Laboratory indicators: anemia, neutropenia, leukopenia, thrombocytopenic purpura,
  • On the part of the gastrointestinal tract: nausea and vomiting, taste change, dysbiosis, stomatitis, glossitis, diarrhea, pseudomembranous enterocolitis, abnormal liver function,
  • Nervous system disorders: ataxia, depression, confusion, anxiety, agitation, insomnia, behavior change, dizziness, headache, peripheral neuropathy, convulsions,
  • Other adverse reactions: tachycardia, shortness of breath, vaginal candidiasis, interstitial nephritis, superinfection (especially in people with reduced resistance or chronic diseases).

Symptoms of an overdose of Amoxicillin are nausea, vomiting and diarrhea, leading to disruption of water and electrolyte balance. Treatment consists of gastric lavage, the appointment of saline laxatives and activated carbon and the correction of water and electrolyte balance.

Instructions for use

According to the instructions for use, the dosage regimen of Amoxicillin is strictly individual. Duration of treatment is from 5 to 12 days.

  • For oral administration, a single dose for adults and children over 10 years old (with a body weight of more than 40 kg) is 250-500 mg, with a severe course of the disease — up to 1 g.
  • For children aged 5-10 years a single dose is 250 mg, at the age of 2 to 5 years — 125 mg, for children under 2 years of age the daily dose is 20 mg / kg.
  • For adults and children, the interval between doses is 8 hours. In the treatment of acute uncomplicated gonorrhea, 3 g once (in combination with probenecid).

In patients with impaired renal function with a CC of 10–40 ml / min, the interval between doses should be increased to 12 hours, with CC less than 10 ml / min, the interval between doses should be 24 hours.

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Pregnancy and lactation

Amoxicillin penetrates the placental barrier, in small quantities excreted in breast milk. If you need to use amoxicillin during pregnancy, you should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus.

With caution apply amoxicillin during lactation (breastfeeding).

Dosage and administration

The drug is taken orally. Adults and children over 10 years old (weighing more than 40 kg) are prescribed at 0.5 g (2 capsules) 3 times a day, in severe cases of infection, the dose is increased to 1.0 g (4 capsules) 3 times a day. The maximum daily dose is 6 g (24 capsules).

For the treatment of acute otitis media, appoint 0.5 g (2 capsules) 3 times a day.

Children aged 5 to 10 years (with a body weight of 20 to 40) are prescribed 0.25 g (1 capsule) 3 times a day.

The course of treatment is 5-12 days (for streptococcal infections — at least 10 days).

Patients with creatinine clearance below 10 ml per minute reduce the dose of the drug by 15-50%, with anuria, the dose should not exceed 2 g per day.

For the treatment of uncomplicated gonorrhea, 3.0 g is administered once (preferably in combination with 1.0 g of probenecid).

For the prevention of endocarditis prescribed 3.0 g once for 1 hour before surgery and 1.5 g after 6-8 hours.

For the treatment and prevention of anthrax in adults and children weighing more than 20 kg, 0.5 g (2 capsules) is prescribed every 8 hours for 2 months.

Side effect

Allergic reactions: urticaria, skin hyperemia, erythematous rash, angioedema, rhinitis, conjunctivitis, rarely — fever, arthralgia, eosinophilia, exfoliative dermatitis, erythema multiforme exudative (including erythema syndrome (including Syndrome-Johnson syndrome), anomalous erythema (including erythema syndrome, including erythema syndrome, adrenal erythema, including erythema, including erythema, including erythema) cases — anaphylactic shock.

From the digestive system: change in taste, nausea, vomiting, stomatitis, glossitis, dysbacteriosis, diarrhea, pain in the anus, rarely — pseudomembranous enterocolitis.

Liver and biliary tract: moderate increase in liver transaminases, rarely hepatitis and cholestatic jaundice.

The nervous system (with prolonged use in high doses): agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, convulsions.

Laboratory changes: leukopenia, neutropenia, thrombocytopenic purpura, transient anemia.

Other effects: shortness of breath, tachycardia, interstitial nephritis, pain in the joints, oral and vaginal candidosis, superinfection (especially in patients with chronic diseases or low body resistance).

Application features

Treatment must continue for another 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

In patients with severely impaired renal function, a dose reduction may be required.

Features of the use of the drug in pediatric practice:

Contraindicated in children under 6 years of age (for this dosage form)

Features of drug use in geriatric practice:

Dose adjustment in elderly patients is not required. However, older patients are more likely to have reduced renal function, so caution should be exercised in dose selection and monitoring renal function due to the potential risk of toxic reactions.

Use during pregnancy and lactation. Data on the possible embryotoxic, teratogenic or mutagenic effects of amoxicillin when taken during pregnancy are not available today. When pregnancy is used for life reasons, taking into account the expected effect for the mother and the potential risk to the fetus. Amoxicillin is contraindicated during lactation (breastfeeding should be discontinued during treatment). Amoxicillin penetrates into breast milk, which can lead to the development of sensitization phenomena in a child.

Precautionary measures

In the process of long-term therapy, it is necessary to monitor the state of the function of the blood-forming organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to it, which requires a corresponding change in antibacterial therapy.

When prescribed to patients with sepsis, a bacteriolysis reaction (the Jarish-Herxheimer reaction) is possible (rarely).

Patients with gonorrhea need to perform serological tests for syphilis at the time of diagnosis. In patients receiving amoxicillin, a subsequent serological control for syphilis should be performed after 3 months.

Carefully used in patients prone to allergic reactions.

Impact on the ability to drive motor vehicles and other potentially

dangerous machinery. To use the drug with caution to persons taking long-term amoxicillin in high doses.

Terms and conditions of storage

Amoxicillin, according to the instructions, should be stored at room temperature in a dry and dark place, out of reach of children.

The prepared suspension is stored for 14 days at a temperature of 15-25 ° C.

The shelf life of the drug — 2 years, after which it must be disposed of.

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